Nafcillin

Nafcillin is a semisynthetic penicillin, which is highly resistant to penicillanase enzyme, with uses, actions similar to those of flucloxacillin. Nafcillin is used in the treatment of infections caused by penicillinase-producing strains of staphylococci, that are resistant to benzylpenicillin.

Brands
Adult Dose
Dose: 3 to 6 g/24hrs
Single Dose: 4.5 (4.5)
Frequency: As recommended.
Route: IV
Instructions:
Neonatal
Paedriatic
Characteristics
Nafcillin Sodium is the derivative of Nafcillin. It is of Synthetic origin. . The Molecular Weight of Nafcillin is 454.50. It is weakly acidic drug and Its pKa is 13.98.
Contraindications
Nafcillin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Nafcillin, which give rise to further complications include Urticaria, Hypotension, Hepatitis, Bronchospasm, Cholestatic jaundice, Hemolytic anemia, Hemolytic anemia, Thrombophlebitis, Neutropenia, Pruritis, Prolongation of bleeding time.Nafcillin produces potentially life-threatening effects which include Convulsions, CNS toxicity, Anaphylaxis. which are responsible for the discontinuation of Nafcillin therapy.The symptomatic adverse reactions produced by Nafcillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Abdominal pain, Rashes, Pain, Skin RashX, Swelling, Hypersensitivity reactions, Wheezing.
Indications
Nafcillin is primarily indicated in conditions like Bone and joint infection, Endocarditis, Skin infections, Staphylococcal infections.
Interactions
Nafcillin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAscorbic AcidChloramphenicolCyclosporin ANafcillin sodium may decrease blood levels of cyclosporin.DisulfiramDisulfiram may increase Nafcillin sodium levels.ProbenecidTetracycline (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Urinanalysis Liver Function Tests Periodic BUN and creatinine determinations
Risks
Drug should not be given to Paediatrics, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (after reconstitution) Store at room temperature or refrigerator. Do not Freeze. Use within 48 hrs if refrigerated and within 8 hrs if kept at room temperature. Tab, Caps Store in a well closed container, at room temperature. Do not Freeze. Protect from Sunlight.
Warnings
It should be used with caution in patients with history of allergy, especially to drugs and in patient hypersensitive to penicillin. Care is necessary if very high dose of penicillin is given, especially if renal function is poor. Renal and hematological status should be monitored during prolonged and high dose therapy.
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