Cephaloridine

Cephaloridine is a first generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cephaloridine is very active against gram positive cocci and used in a large variety of bacterial infections, such as respiratory tract, skin and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cephaloridine is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Brands
Adult Dose
Dose: 4.76 to 9.52 mg/kg
Single Dose: 7.1 (7.14)
Frequency: 8 hourly
Route: IM
Instructions: -
Neonatal
Dose: 15 mg/kg
Single Dose: 15 (15)
Frequency: 12 hourly
Route: Intramuscular
Instructions:
Paedriatic
Dose: 2.5 mg/kg
Single Dose: 2.5 (2.5)
Frequency: 24 hourly
Route: Intra Thecal
Instructions: -
Characteristics
. It is of Semi Synthetic origin and belongs to Cephem Carboxylate. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Cephaloridine is 415.50. Its pKa is 3.4.
Contraindications
Cephaloridine is contraindicated in conditions like Blood dyscrasias,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Cephaloridine, which give rise to further complications include Eosinophilia, Eosinophilia, Increased prothrombin time, Abnormalities of blood coagulation, Anaphylaxis.Cephaloridine produces potentially life-threatening effects which include Renal damage. which are responsible for the discontinuation of Cephaloridine therapy.The signs and symptoms that are produced after the acute overdosage of Cephaloridine include Convulsions, Coma, Myoclonus, Hallucinations, Nystagmus.The symptomatic adverse reactions produced by Cephaloridine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rash, Cross reactions, Allergic diathesis.
Indications
Cephaloridine is primarily indicated in conditions like Bacterial infections, Bronchitis, Gonorrhoea, and can also be given in adjunctive therapy as an alternative drug of choice in Corneal ulcers, Intraocular infections.
Interactions
Cephaloridine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmikacin (Sulphate)Ethacrynic AcidFrusemide or FurosemidePenicillamineReviparin SodiumCephaloridine may potentiate the action of Reviparin.Tobramycin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store . Protect from Sunlight, Moisture and Heat.
Warnings
Cephaloridine should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).
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