Paromomycin (Sulphate)

Paromomycin (Sulphate) is an aminoglycoside antibiotic. The antibacterial spectrum is similar to that of neomycin, but is also effcetive against some protozoa, including Leishmania spp., Entamoeba histolytica, and crytosporidium spp.and anthelminitic properties against tape worms. Cross resistance may produce beween paromomycin and kanamycin, neomycin and streptomycin. Paromomycin (Sulphate) is used in the treatment of intestinal protozoal infections, including amoebiasis, cryptosporidiosis, visceral or cutaneous leishmmaniasis and giardiasis. It may also be used in the treatment of tapeworm infection.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Paromomycin (Sulphate) is 615.60. It is weakly acidic drug.
Contraindications
Paromomycin (Sulphate) is contraindicated in conditions like Intestinal obstruction,Amebiasis,Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Paromomycin (Sulphate), which give rise to further complications include Nephrotoxicity, Ototoxicity.The symptomatic adverse reactions produced by Paromomycin (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Nausea and vomiting.
Indications
Paromomycin (Sulphate) is primarily indicated in conditions like Amoebiasis, Cryptosporidiosis, Giardiasis, Hepatic encephalopathy, Intestinal protozoal infection.
Interactions
Paromomycin (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcarboseDigoxinMethotrexateThe combined use of methotrexate and paromomycin decreases the GI absorption of methotrexate result in reduced efficacy of methotrexate.ModerateClosely monitor for altered efficacy and safety of methotrexate. Consider intravenous route of administration (for methotrexate) to avoid interaction.Phenoxymethylpenicillin (K) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Cap, syrup Store in a well closed container.
Warnings
It should be used with caution in patients who are sensitive to aminoglycosides. Take appropriate measures in case of secondry infections.
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