Glucagon (HCl)

Glucagon (HCl) is a polypeptide hormone that is produced by alpha-cells of pancreas. Glucagon (HCl) is a hyperglycaemic (increases blood glucose level) that mobilises glucose by activating glycogenolysis. It causes release of several other hormones, and also increases cardiac muscles contraction. Glucagon (HCl) is used in tests of carbohydrate metabolism and also for the management beta-blocker overdosage.

Brands
Adult Dose
Dose: 1 to 2 mg
Single Dose: 1.5 (1.5)
Frequency: As recommended.
Route: IM
Instructions: As a diagnostic aid
Neonatal
Paedriatic
Characteristics
. It is of Natural origin. . The Molecular Weight of Glucagon (HCl) is 3482.80.
Contraindications
Glucagon (HCl) is contraindicated in conditions like Phaeochromocytoma.
Effects
The severe or irreversible adverse effects of Glucagon (HCl), which give rise to further complications include Hypokalemia.The symptomatic adverse reactions produced by Glucagon (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal pain, Hypotension, Nausea and vomiting, Hypersensitivity reactions.
Indications
Glucagon (HCl) is primarily indicated in conditions like Severe hypoglycemic reactions, and can also be given in adjunctive therapy as an alternative drug of choice in Poisoning.
Interactions
Glucagon (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementInsulin GlulisineGlucagon, corticosteroids, niacin, diuretics, sympathomimetic agents (e.g., epinephrine, albuterol, terbutaline), phenothiazine derivatives, thyroid hormones, progestogens (e.g., in oral contraceptives), protease inhibitors, and atypical antipsychotics may reduce the blood-glucose-lowering effect.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Serum glucose level
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store in a well closed container, at room temperature, Below 15°C. Inj (reconstituted soln) Store in a well closed container. Refrigeration is recommended. Use within 48 hrs if kept at room temperature.
Warnings
It should be administered with caution to patient with insolinoma as it may induce hypoglycemia due to its insline releasing effects. Caution is also required when it is being employed as a diagnostic aid in diabetic patients. Glucagon is not effective in patients with marked depletion of liver glycogen stores, as in starvation, adrenal insufficiency or chronic hypoglycemia. Should be cautiously given in adrenal insufficiency.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.