Plicamycin

Plicamycin is a cytotoxic antibiotic with hypocalcaemic properties. It acts by complexing with DNA in the presence of divalent cations and inhibiting synthesis of ribonucleic acid. The hypocalcaemic activity is due to the antagonist effect on vitamin D and parathyroid hormone on osteoclasts. Plicamycin is used in the symptomatic management of hypercalcaemiaand hypercalciuria associated with malignancy. Plicamycin is also usedin the treatment of neoplasms of the testis not susceptible to surgery or radiotherapy. It was approved by FDA in 1970.

Brands
Adult Dose
Dose: 25 to 30 mcg/kg of body weight
Single Dose: 28 (27.5)
Frequency: As recommended.
Route: IV
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Plicamycin is 1085.00. It is weakly acidic drug.
Contraindications
Plicamycin is contraindicated in conditions like Thrombocytopenia,Pregnancy,Coagulation disorder.
Effects
The severe or irreversible adverse effects of Plicamycin, which give rise to further complications include Thrombocytopenia, Coagulation disorder, Phlebitis, Depressed bone marrow function.Plicamycin produces potentially life-threatening effects which include Hemorrhage. which are responsible for the discontinuation of Plicamycin therapy.The symptomatic adverse reactions produced by Plicamycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Headache, Drowsiness, Fever, Skin RashX, Lethargy, Malaise, Facial flushing, Depression, Local irritation.
Indications
Plicamycin is primarily indicated in conditions like Hypercalcaemia, Hypercalciuria, Malignant neoplasm of testis.
Interactions
No data regarding the interactions of Plicamycin was found.
Interfrence
Abnormal LFTs Increased Alkaline Phosphatase LevelsAbnormal renal function testIncreased in serum creatininElevation in BUN
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inf (reconstituted) Store at room temperature. Protect from Sunlight. Use within 4-6 hrs if kept at room temperature. Inj (reconstituted soln) Protect from Sunlight.
Warnings
It should noly be given with great caution in patient with impaired hepatic or renal function. Blood cell counts, bleeding time, prothrombin time, hepatic and renal function should be detremined frequently during treatment and for several days after, and treatment stoppped if there is any sudden change.
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