Tiagabine (HCl)

A nipecotic acid derivative and was rationally designed as an inhibitor of GABA uptake. It is used as second line drug in the treatment of epilepsy, as adjunctive therapy for refractory partial seizures with or without secondary generalization.


Brands
Adult Dose
Dose: 4 mg
Single Dose: 4 (4)
Frequency: 24 hourly
Route: PO
Instructions: Increase by 4 to 8 mg at wk intervals until clinical response achieved.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Tiagabine (HCl) is 412.00.
Contraindications
Tiagabine (HCl)
Effects
The severe or irreversible adverse effects of Tiagabine (HCl), which give rise to further complications include Nystagmus, Tremors.The symptomatic adverse reactions produced by Tiagabine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Diarrhea, Fever, Nervousness, Chills, Confusion, Depression, Nausea and vomiting, Bruising.
Indications
Tiagabine (HCl) is primarily indicated in conditions like Epilepsy, Refractory partial seizures.
Interactions
Tiagabine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineCarbamazepine reduces plasma concentration of Tigabine.PhenobarbitonePhenytoin (Na)VORICONAZOLEVoriconazole may increase the serum concentration of tiagabine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature. Protect from Sunlight and Moisture.
Warnings
Dosage should be reduced and/or the dosage intervals increased in patients with hepatic impairment because hepatic metabolism of tiagabine is reduced in such patients.
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