Aminocaproic Acid

Aminocaproic Acid is an antifibrinolytic, and a haemostatic agent. It binds to lysine-binding sites within the plasminogen/plasmin molecule. This interferes with the ability of plasmin to lyse fibrin clots. Aminocaproic Acid is used in the treatment of systemic or urinary hyperfibrinolysis, such as may be encountered with disorders such as aplastic anaemia, abruptio placentae, hepatic cirrhosis, neoplastic disease such as carcinoma of the prostate, lung, stomach, or cervix, and following cardiac surgery (with or without by-pass procedures).

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Aminocaproic Acid is 131.20. It is weakly alkaline drug and Its pKa is 4.43.
Contraindications
Aminocaproic Acid
Effects
The severe or irreversible adverse effects of Aminocaproic Acid, which give rise to further complications include Cardiac arrhythmias, Hypotension, Bradycardia.Aminocaproic Acid produces potentially life-threatening effects which include Convulsions, Cardiac & hepatic damage. which are responsible for the discontinuation of Aminocaproic Acid therapy.The signs and symptoms that are produced after the acute overdosage of Aminocaproic Acid include Renal failure, Muscle damage.The symptomatic adverse reactions produced by Aminocaproic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Tinnitus, Skin RashX, Nasal congestion, GI disturbance.
Indications
Aminocaproic Acid is primarily indicated in conditions like Acute spasm and spasm in diagnostic procedures, Haemorrhage.
Interactions
No data regarding the interactions of Aminocaproic Acid was found.
Interfrence
Risks
Drug should not be given to Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Syrup, Inj Store at room temperature. Do not Freeze. Tab Store in a well closed container, at room temperature.
Warnings
It should be used with care in patient with renal or cardiac disorder. It is advisable to monitor creatine phosphokinase values for sings of muscle damage.
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