Iron Dextran

Iron Dextran is a complex of ferric hydroxide with dextran. It should be used only in the treatment of proven iron-deficiency anaemia, where oral therapy is ineffective or inappropriate.Iron Dextran is given through deep IM injection. Parenteral iron produces clinical responses similar to that of oral iron, but stores are rapidly repleted after the administration of parenteral iron, which may take months to achieve with oral iron therapy. Anaphylactoid reactions can take place following parenteral administration of it. It was approved by FDA in early 80s.

Brands
COSMOFER
Adult Dose
Neonatal
Paedriatic
Dose: 10 to 100 mg
Single Dose: 55 (55)
Frequency: 24 hourly
Route: IV
Instructions: Dose varies according to weight.
Characteristics
. It is of Synthetic origin and belongs to Ferric hydroxide, Dextran. . The Molecular Weight of Iron Dextran is 133.00.
Contraindications
Iron Dextran is contraindicated in conditions like Asthma,Liver diseases.
Effects
The severe or irreversible adverse effects of Iron Dextran, which give rise to further complications include Tachycardia, Hypotension, Hypotension, Bradycardia, Thrombophlebitis, Hypertension, Shock, Myocardial infarction, Peripheral vascular flushing, Tachycardia.Iron Dextran produces potentially life-threatening effects which include Fatal allergic reactions, Decreased BP. which are responsible for the discontinuation of Iron Dextran therapy.The symptomatic adverse reactions produced by Iron Dextran are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Nausea, Vomiting, Diarrhea, Fever, Myalgia, Abdominal pain, Chills, Urticaria, Pruritus, Flushing, Taste disturbance, Phlebitis, Arthralgia, Syncope, Chest pain, Metallic taste, Paresthesias, Chest tightness, Reaction at injection site, dizziness.
Indications
Iron Dextran is primarily indicated in conditions like Anaemia, Iron deficiency anaemia.
Interactions
Iron Dextran is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementChloramphenicolEnalapril (Maleate)Technetium Tc-99m OxidronatePossible accumulation of technetium Tc 99m oxidronate at site[s] of injection of Iron Dextran. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Falsely elevated values of serum bilirubinFalsely decreased values of serum calcium
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV Inj, IM Inj Store at room temperature. Protect from Sunlight.
Warnings
It should be used with caution in patients with a history of allergic disorders or asthma and in these patients the intramuscular and not the intravenous rout should be employed. Large doses of iron dextran by infusion may lead to serum discololartion. Prior to beginning treatment patients should receive a test dose and should be observed for adverse reactions. Patient should be kept under observation for atleast 1 hour after administration of test dose.
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