Lacidipine

Lacidipine is a calcium-channel blocking agent, actions, uses and adverse effects similar to those of nifedipine. Lacidipine is used for the management of hypertension.


Brands
Adult Dose
Dose: 2 mg
Single Dose: 2 (2)
Frequency: 24 hourly
Route: PO
Instructions: May be given upto 4-6 mg/day if needed
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Dihydropyridine. . The Molecular Weight of Lacidipine is 455.50.
Contraindications
Lacidipine is contraindicated in conditions like Hypersensitivity,Aortic stenosis,Left ventricular dysfunction.
Effects
The severe or irreversible adverse effects of Lacidipine, which give rise to further complications include Hypotension, Hypotension, Exacerbated angina, Gingival hypertrophy.The signs and symptoms that are produced after the acute overdosage of Lacidipine include Tachycardia, Prolonged peripheral vasodilation.The symptomatic adverse reactions produced by Lacidipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Dyspnea, Palpitation, Flushing, Polyuria, Muscle cramps, Paresthesias, Ankle edema, Hypotensive crisis, Sexual impotence, Cold legs, dizziness.
Indications
Lacidipine is primarily indicated in conditions like Hypertension.
Interactions
Lacidipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAtenololEnhanced hypotensive effects when beta-blockers (e.g Atenolol) given with calcium-channel blockers (e.g Lacidipine).Cimetidine (HCl)DigoxinPropranolol (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Below 30°C. Protect from Sunlight.
Warnings
Lacidipine should be used with caution in patients with kidney or liver disease. Consider decrease in dose of calcium channel blockers and monitor drug response in cirrhosis patients. It should be used with caution in the patient with hypotension. It should not be used in the cardiogenic shocks, recent Myocardial Infarction and in acute unstable angina. Sudden withdrawal of lacidipine might be associated with an exacerbation of angina. The drug should be discontinued in the patient who experience ischaemic pain following its administration.
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