Interferon Gamma

Interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The interferones bind to specific cell-surface receptors that initiate a series of intracellular events, induction of certain enzymes, inhibition of cell-proliferation, and enhancement of immune activities. it-1b is a parenteral recombinant DNA drug that is essentially identical to natural gamma interferon. Interferon Gamma is chemically and pharmacologically distinct from interferon alfa or interferon beta. Recombinant it-1b is derived from genetically engineered Escherichia coli and is currently used in the treatment of chronic granulomatous disease, an inherited disorder of phagocytic oxidative metabolism. it-1b was approved by the FDA in December 1990. I

Brands
Adult Dose
Dose: 1.5 mcg/kg/dose
Single Dose: 1.5 (1.5)
Frequency: As recommended.
Route: SC
Instructions: For patients whose body surface area is less than 0.5 m2.
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to Cytokines. . The Molecular Weight of Interferon Gamma is 20000.00. Its pKa is 8.6 - 8.7.
Contraindications
Interferon Gamma is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Interferon Gamma, which give rise to further complications include Bronchospasm, Pancreatitis, Neutropenia, Hyponatremia, Interstitial pneumonitis, Hypoglycemia, Hepatic insufficiency, Renal insufficiency.Interferon Gamma produces potentially life-threatening effects which include Myocardial infarction, GI bleeding, Pulmonary embolism, Heart failure. which are responsible for the discontinuation of Interferon Gamma therapy.The signs and symptoms that are produced after the acute overdosage of Interferon Gamma include Ataxia, Dizziness, Clouding of conciousness.The symptomatic adverse reactions produced by Interferon Gamma are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Fatigue, Nausea, Vomiting, Fever, Myalgia, Chills, Parkinsonism, Arthralgia, Syncope, Tachypnea.
Indications
Interferon Gamma is primarily indicated in conditions like Chronic granulomatonus disease, and can also be given in adjunctive therapy as an alternative drug of choice in Adjunct in the treatment of opiod dependence, Leishmaniasis, Lepromatous leprosy, Oncological indications.
Interactions
No data regarding the interactions of Interferon Gamma was found.
Interfrence
Liver Function Test (LFT) Elevation in ALT or ASTComplete blood cell count
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 12 hrs if kept at room temperature. SC Inj Store in refrigerator. Do not Freeze.
Warnings
It should be used with caution in patients with any pre-existing liver, kidney, heart or thyroid disease, blood disorders, history of depression or other mental condition, lung disease, diabetes, seizures, brain tumor, multiple sclerosis, lupus, sarcoidosis or any drug allergy. It should be used with caution when engaging in activities requiring alertness. Limit alcohol intake. It should be used only when clearly needed during pregnancy. Im injection should be administered with caution in the patients receiving Interferon gamma. The drug is contraindicated in the patient with the prior history of E.coli protein hypersensitivity.
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