Interferon Beta

Interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The interferones bind to specific cell-surface receptors that initiate a series of intracellular events, induction of certain enzymes, inhibition of cell-proliferation, and enhancement of immune activities. It (IFNB) is a type of interferon produced by fibroblasts and epithelial cells. The term "it" used here encompasses products that are further differentiated as either it-1a or it-1b. it-I a, a 166-amino acid recombinant glycoprotein, and it-I b, a 165-amino acid recombinant protein, used in the treatment of multiple sclerosisto reduce the frequency of clinical exacerbations.

Brands
BETAFERON
Adult Dose
Dose: 0.25 mg
Single Dose: 0.25 (0.25)
Frequency: As recommended.
Route: SC
Instructions: Should be injected every other day. Generally, patients should be started at 0.0625 mg (0.25 mL) subcutaneously every other day, and increased over a six week period to 0.25 mg (1.0 mL) every other day
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to cytokines. . The Molecular Weight of Interferon Beta is 20025.38. Its pKa is 7.2-7.8.
Contraindications
Interferon Beta is contraindicated in conditions like Depression,Lactation.
Effects
The severe or irreversible adverse effects of Interferon Beta, which give rise to further complications include Sinus tachycardia, Neutropenia, Hypothyroidism, Depression, Pancytopenia, Hyperthyroidism.The symptomatic adverse reactions produced by Interferon Beta are more or less tolerable and if they become severe, they can be treated symptomatically, these include Alopecia, Anorexia, Fever, Skin reactions, Confusion, Malaise, Arthralgia, Swelling, Anemia, Muscle aching, Leukopenia, Skin redness, Lymphopenia, Confusion, Alopecia.
Indications
Interferon Beta is primarily indicated in conditions like Condyloma acuminata, Hairy cell leukaemia, Hepatitis B, Hepatitis C, Herpes simplex infections, Multiple sclerosis.
Interactions
No data regarding the interactions of Interferon Beta was found.
Interfrence
Thyroid Function TestLiver Function Test (LFT)
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IM Inj Store Below 25°C. Inj (reconstituted soln) Store at room temperature. Use within 3 hrs if kept at room temperature. SC Inj Store in refrigerator. Do not Freeze.
Warnings
It should be used with caution in patients with any pre-existing liver, kidney, heart or thyroid disease, blood disorders, history of depression or other mental condition, lung disease, diabetes, seizures, brain tumor, multiple sclerosis, lupus, sarcoidosis or any drug allergy. It should be used with caution when engaging in activities requiring alertness. Limit alcohol intake. It should be used only when clearly needed during pregnancy.
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