Ibutilide (Fumarate)

Ibutilide (Fumarate) is a substituted methane sulfonamide derivative, belongs to class III antiarrhythmic. Ibutilide (Fumarate) is indicated for rapid conversion of atrial fibrillation or atrial flutter to normal sinus rhythm. Ibutilide (Fumarate) is approved by FDA in December 28, 1995.


Brands
Adult Dose
Dose: 0.1 ml/kg
Single Dose: 0.1 (0.1)
Frequency: As recommended.
Route: IV
Instructions: For less than 60 kg. If the arrhythmia does not terminate within 10 min after the end of the initial infusion, a second 10 min infusion of equal strength may be administered 10 min after completion of the first
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Methanesulfonamide. . The Molecular Weight of Ibutilide (Fumarate) is 884.00. Its pKa is 8.4, 9.6.
Contraindications
Ibutilide (Fumarate) is contraindicated in conditions like Hypersensitivity,Pregnancy,Ventricular tachyarrhythmias,Torsade de pointes.
Effects
The severe or irreversible adverse effects of Ibutilide (Fumarate), which give rise to further complications include Sinus tachycardia, Hypertension, Torsades de pointes, QT prolongation.Ibutilide (Fumarate) produces potentially life-threatening effects which include Polymorphic ventricular tachycardia. which are responsible for the discontinuation of Ibutilide (Fumarate) therapy.The signs and symptoms that are produced after the acute overdosage of Ibutilide (Fumarate) include Ventricular ectopy.The symptomatic adverse reactions produced by Ibutilide (Fumarate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Diarrhea, Hypotension, Renal failure, AV Block, Sinus bradycardia, Supraventricular tachycardia, Nodal arrhythmias, Congestive heart failure, Idioventricular rhythm, dizziness.
Indications
Ibutilide (Fumarate) is primarily indicated in conditions like Atrial fibrillation, Atrial flutter, Ventricular tachycardia.
Interactions
Ibutilide (Fumarate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 20°C-25°C. Protect from Sunlight.
Warnings
The ECG should be monitored continuously during infusion and for at least 4 hours after administration. The infusion should be stopped as soon as the arrhythmia is terminated.
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