Hirudin

Hirudin is a protein consists of 65-amino-acid, that is a direct inhibitor of thrombin. It has been extracted from leeches and this form is used in various topical preparations. Whereas, the recombinant form includes Lepirudin and Desirudin. Lepirudin is used as an anticoaggulant in patients with heparin induced thrombocytopenia, who require parenteral antithrombotic treatment. Rcombinant forms may also be used in myocardial infarction (MI) and unstable angina.

Brands

Adult Dose

Neonatal

Paedriatic

Dose: 0.1 mg/kg/hour
Single Dose: 0.1 (0.1)
Frequency: 2 hourly
Route: Bolos
Instructions: For myocardial infarction.

Characteristics

. It is of Natural/Synthetic origin. . The Molecular Weight of Hirudin is 6964.00. Its pKa is 4.4.

Contraindications

Hirudin is contraindicated in conditions like Hypersensitivity,Bleeding diathesis.

Effects

Hirudin produces potentially life-threatening effects which include Hemorrhage. which are responsible for the discontinuation of Hirudin therapy.The symptomatic adverse reactions produced by Hirudin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergic reactions, Acute urticaria.

Indications

Hirudin is primarily indicated in conditions like Deep vein thrombosis, Hemodialysis, Heparin induced thrombocytopenia, Thrombolytic therapy in acute myocardial infarction, Unstable angina.

Interactions

No data regarding the interactions of Hirudin was found.

Interfrence

Elevates thrombin and partial thrombin time and interferes with other coagulation test

Risks

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Warnings

Doses of hirudin should be reduced in patient with renal impairment. It must be administered parentrally and is monitored by the PTT.

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