Hydromorphone

Hydromorphone is in a group of drugs called narcotic pain relievers. Hydromorphone (HCl) is a phenantherne derivative with agonist activity on opiate receptors. Hydromorphone (HCl) is a, semisynthetic analog of morphine, but more potent than morphine. Due to its potency, Hydromorphone (HCl) is often used to relieve severe pain in cancer patients, although its short duration of action can limit its utility. Although all opiates can potentially suppress the cough reflex, hydromorphone is rarely used for this purpose. The drug is available for oral use as well as for parenteral administration. Hydromorphone is a schedule C-II controlled substance and was approved by the FDA in 1984.

Brands
Adult Dose
Dose: 2.5 to 10 ml
Single Dose: 6.2 (6.25)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 0.5 mg
Single Dose: 0.5 (0.5)
Frequency: 6 hourly
Route: PO
Instructions: Child 6-12 year for non productive cough
Characteristics
Hydromorphone also known as Phennathrene. Hydromorphone (HCl) is the derivative of Hydromorphone. It is of Semi Synthetic origin and belongs to Morphine. . The Molecular Weight of Hydromorphone is 321.80. Its pKa is 8.08, 9.47.
Contraindications
Hydromorphone is contraindicated in conditions like Hypovolaemia,Hypotension,Hypersensitivity,Respiratory insufficiency.
Effects
The severe or irreversible adverse effects of Hydromorphone, which give rise to further complications include Insomnia, Seizures, Respiratory depression, Constipation.Hydromorphone produces potentially life-threatening effects which include Respiratory depression, Respiratory arrest, Cardiac Arrest, Cardiac arrest, Shock, Circulatory depression. which are responsible for the discontinuation of Hydromorphone therapy.The signs and symptoms that are produced after the acute overdosage of Hydromorphone include Drowsiness, Confusion, Fainting, Pinpoint pupils, Shallow breathing, Death due to respiratory depression.The symptomatic adverse reactions produced by Hydromorphone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Drowsiness, Nausea, Vomiting, Restlessness, Constipation, Sweating, Dry mouth, Blurred vision, Confusion, Sedation, Agitation, Paresthesias, Uretheral spasm, Dry mouth, Confusion, dizziness.
Indications
Hydromorphone is primarily indicated in conditions like Biliary colic, Bone trauma, Burns, Cough, Cough suppressant, Non productive cough, Pain, Pain management in cancer patient, Post operative analgesia, Renal colic.
Interactions
No data regarding the interactions of Hydromorphone was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store Below 25°C. Protect from Sunlight and Moisture. Oral Liq Store Between 15°C-25°C. Protect from Sunlight. Suppositories Store in refrigerator. Protect from Sunlight. Tab, SC Inj, IM Inj, IV Inj Store at room temperature. Protect from Sunlight.
Warnings
It should be used with caution or in a reduced doses to patients with hypothyroidism, adrenocortical insufficiency, asthma, impaired kidney or liver function, prostatic hyperplasia, hypotension, shock, inflammatory or obstructive bowel disorders or mysthania gravis. Discontinuation of therapy with opioid analgesic should be carried out gradually to avoiding precipitating withdrawal symptoms in patients who may have developed physical dependence. Donot use alcohol. Avoid taking other drugs which make you sleepy. Donot drive as Hydromorphone may cause drowziness. Take this drug with food to avoid upset stomach.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.