Granisetron (HCl)

Granisetron is an oral and parenteral antiemetic agent. Granisetron (HCl) is commonly used to treat nausea and vomiting from highly emetogenic cancer chemotherapy. The actions, uses and adverse effects similar to those of ondansetron, but unlike ondansetron, Granisetron (HCl) is not approved for postoperative emesis. Granisetron selectively blocks type 3 serotonin (5-HT3) receptors. 5-HT3 receptors are found centrally in the chemoreceptor trigger zone and peripherally at vagal nerve terminals in the intestines. Whether the action of granisetron is mediated centrally, peripherally, or a combination of both remains to be determined.Granisetron injection was approved by the FDA on December 29, 1993. The oral dosage form was subsequently approved March 20, 1995 and has been shown to be as effective as IV ondansetron for chemotherapy-induced nausea and vomiting.

Brands
GRANISET GRANISET GRANITON GRANITON KYTRIL KYTRIL GRANICIP EUROTRON GRATRON
Adult Dose
Dose: 3 mg
Single Dose: 3 (3)
Frequency: As recommended.
Route: IV-Inf (over 5 min)
Instructions: Prevention, before start of chemotherapy (up to 2 additional doses may be given within 24 hrs).
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Inazole. . The Molecular Weight of Granisetron (HCl) is 348.90.
Contraindications
Granisetron (HCl) is contraindicated in conditions like Hypersensitivity,Sub-acute intestinal obstruction.
Effects
The signs and symptoms that are produced after the acute overdosage of Granisetron (HCl) include Headache.The symptomatic adverse reactions produced by Granisetron (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Constipation, Rashes, Hypersensitivity reactions, Decreased GI motility.
Indications
Granisetron (HCl) is primarily indicated in conditions like Nausea and vomiting (chemotherapy induced), Nausea and vomiting (chemotherapy induced), prevention, Nausea and vomiting associated with chemotherpy, Post operative vomiting, Post-operative nausea and vomiting.
Interactions
No data regarding the interactions of Granisetron (HCl) was found.
Interfrence
None well documented
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 24 hrs if kept at room temperature. IV Inj, IV Inf, Oral Soln Store at room temperature, Below 30°C. Do not Freeze. Protect from Sunlight. Tab Store at room temperature. Protect from Sunlight.
Warnings
Dosage ristriction is advisable in patients with moderate to severe liver impairment. It should be used with caution during pregnancy or lactation.
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