Gestrinone

Gestrinone is a synthetic steroidal hormone that exhibits androgenic, anti-oestrogenic and anti-progestogenic properties. it reduces the size of endometrial tissue fragments and leads to their regression, therefore Gestrinone is used mainly for treatment of endometriosis. It may inhibit ovulation and menstrual irregularities such as breakthrough bleeding may occur during treatment.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Trienic 19-Nortestosterane. . The Molecular Weight of Gestrinone is 308.40.
Contraindications
Gestrinone is contraindicated in conditions like Cardiac insufficiency,Pregnancy,Lactation,Metabolic or vascular disorders,Renal insufficiency,Hepatic insufficiency.
Effects
The symptomatic adverse reactions produced by Gestrinone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nervousness, Cramps, Depression, Weight gain, Fluid retention, Hot flushes, Acne, Hirsutism, Changes in libido, GI disturbance, Oily skin, Voice changes, Light vaginal bleeding, Irregular bleeding, nervousness, Nervousness, changes in libido, Deepening of voice.
Indications
Gestrinone is primarily indicated in conditions like Endometriosis, and can also be given in adjunctive therapy as an alternative drug of choice in Benign breast disease, Fibroids, Intracranial meningiomas, Menorrhagia.
Interactions
No data regarding the interactions of Gestrinone was found.
Interfrence
Decreased concentration of thyroid binding globulin,decreased in serum total thyroxine level
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Store Below 30°C. Caps Store Below 25°C. Protect from Sunlight.
Warnings
It should not be used during pregnancy or lactation. It should be used with caution in-patients with migraine headaches, heart, liver or kidney disease, a history of seizures, breast cancer, abnormal bleeding, previous strokes, prostate cancer or any other diseases. Extreme caution is advised for use in children. Pediatric specialist consultation is also advised. Geriatric men are at increased risk of developing enlarged prostate and prostate cancer with the use of androgen-like drugs, so use cautiously.
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