Gallium Nitrate

Gallium Nitrate is an inorganic metallic salt that inhibits bone resorption and is used for its hypocalcaemic properties. Gallium Nitrate is used in the treatment of hypercalcaemia associated with malignant neoplasmsn and in other disorders associated with abnormally enhanced bone turn over e.g Paget`s disease of bone.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Inorganic Metalic salt. . The Molecular Weight of Gallium Nitrate is 417.90.
Contraindications
Gallium Nitrate is contraindicated in conditions like Renal insufficiency.
Effects
Gallium Nitrate produces potentially life-threatening effects which include Acute Renal Failure, Colitis, Acute renal failure, Optic neuritis, Bloody diarrhea, Ocular pain, Decreased visual acuity. which are responsible for the discontinuation of Gallium Nitrate therapy.The signs and symptoms that are produced after the acute overdosage of Gallium Nitrate include Nausea, Vomiting, Renal insufficiency.The symptomatic adverse reactions produced by Gallium Nitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Fever, Tachycardia, Tinnitus, Hypotension, Muscle cramps, Peripheral neuropathy, Metallic taste, Anemia, Leukopenia, Hypophosphatemia, Hypocalcemia, Tetany, Mild respiratory alkalosis, Pleural effusion, Decreased hearing, Rash, Hypotension, Tachycardia, Lower extremity edema.
Indications
'Gallium Nitrate is primarily indicated in conditions like Hypercalcaemia due to malignancy, and can also be given in adjunctive therapy as an alternative drug of choice in Bladder carcinoma, Bone (pagets) disease, Bone metastasis, Non-hodgkin''s lymphoma, Non-hodgkin''s lymphoma, Postmenopausal disorders.'
Interactions
No data regarding the interactions of Gallium Nitrate was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inf (reconstituted) Store at room temperature or refrigerator. Use within 7 days if refrigerated and within 48 hrs if kept at room temperature. Inj Store at room temperature.
Warnings
It should be use with caution in patients with with impaired renal function. Administer to a pregnant woman only if clearly needed because it is category C drug. Closely monitor renal function and serum calcium during gallium nitrate therapy patient should be well hydrated and have good renal out put before starting the infusion.
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