Gabapentin

Gabapentin is an antiepileptic that is used as an adjunctive treatment of partial seizures with or without secondary generalisation. Gabapentin is also used for the treatmnet of neuropathic pain.


Adult Dose
Dose: 900 to 1800 mg
Single Dose: 1400 (1350)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to GABA. . The Molecular Weight of Gabapentin is 171.30. Its pKa is 3.7,10.7.
Contraindications
Gabapentin is contraindicated in conditions like Myoclonic seizures,Penconceptual period.
Effects
The signs and symptoms that are produced after the acute overdosage of Gabapentin include Diarrhea, Slurred speech.The symptomatic adverse reactions produced by Gabapentin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Drowsiness, Fatigue, Ataxia, Rashes, Confusion, Dyspepsia, Weight gain, Somnolence, Tremor, Diplopia, Asthenia, Arthralgia, Unsteadiness, Purpura, UTI, Amnesia, Leucopenia, Confusion, Abnormal thinking, dizziness, dyspepsia, Ataxia.
Indications
Gabapentin is primarily indicated in conditions like Epilepsy, Neuropathic pain, Partial seizures, Partial seizures with 2ndry generalization.
Interactions
Gabapentin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCimetidine (HCl)FosphenytoinPhenytoin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve dipstick test for Urinary Protein
Risks
Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store at room temperature.
Warnings
It should be use cautiously in patients with impaired renal function. Withdrawl of therapy or transition to or from another type of antiepileptic therapy should be made gradually to avoid precipitating an increase in the frequency of seizures.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.