Felbamate

Felbamate is a carbamate structurally related meprobamate. Felbamate is used in the treatment of epilepsy. Felbamate is used alone or in combination with other agents for refractory partial seizures with or without secondary generalisation.


Brands
Adult Dose
Dose: 3.6 g
Single Dose: 3.6 (3.6)
Frequency: 6 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Dose: 15 to 45 mg/kg
Single Dose: 30 (30)
Frequency: 4 hourly
Route:
Instructions:
Characteristics
Felbamate also known as Felbamato, Felbamato. . It is of Synthetic origin. . The Molecular Weight of Felbamate is 238.24.
Contraindications
Felbamate is contraindicated in conditions like Blood dyscrasias,Bone marrow depression,Hepatic dysfunction,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Felbamate, which give rise to further complications include Stevens johnson syndrome, Stevens johnson syndrome.Felbamate produces potentially life-threatening effects which include Aplastic Anemia, Hepatic failure, Aplastic anemia. which are responsible for the discontinuation of Felbamate therapy.The signs and symptoms that are produced after the acute overdosage of Felbamate include Gastric distress, Increased heart rate.The symptomatic adverse reactions produced by Felbamate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Insomnia, Somnolence, Hypokalemia, Hypophosphatemia, dizziness.
Indications
Felbamate is primarily indicated in conditions like Partial seizures, Seizures associated with lennox gastaut syndrome.
Interactions
Felbamate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineFosphenytoinPhenytoin (Na)VORICONAZOLEVoriconazole may increase the serum concentration of felbamate by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of felbamate if voriconazole is initiated, discontinued or dose changed.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store at room temperature.
Warnings
Complete blood counts and liver function tests should be carried out before the patient starts treatment and regularly during tretament. The drug should be discontinued if there is any evidence of bone marrow deppressio or liver abnormalities. Take protective measures against exposure to UV radiation because drug may cause photosensitivity reaction. Also with renal impairment.
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