Esmolol

Esmolol is a cardioselective short-acting beta-blocker. Esmolol is administered via IV-infusion and due to ultra short duration of action, is useful for acute control of hypertension or certain supraventricular arrhythmias. Esmolol is also used to control hypertension and tachycardia in perioperative, postoperative or emergency settings.

Brands
Adult Dose
Dose: 1.5 mg/kg
Single Dose: 1.5 (1.5)
Frequency: As recommended.
Route: IV
Instructions: For the management of postintubation tachycardia and hypertension, should be given as a bolus injection (over 30 seconds) 1 to 2 minutes before intubation.
Neonatal
Paedriatic
Dose: 25 to 350 mcg/kg/min
Single Dose: 190 (187.5)
Frequency: As recommended.
Route: IV
Instructions:
Characteristics
. It is of Synthetic origin and belongs to Benzenepropanoic Acid. . The Molecular Weight of Esmolol is 331.80. Its pKa is 9.5.
Contraindications
Esmolol is contraindicated in conditions like Diabetes mellitus,Cardiogenic shock,Bronchospasm,Heart block,Hypotension,Sinus bradycardia.
Effects
The severe or irreversible adverse effects of Esmolol, which give rise to further complications include Hypotension, Hypotension.Esmolol produces potentially life-threatening effects which include Bradycardia. which are responsible for the discontinuation of Esmolol therapy.The signs and symptoms that are produced after the acute overdosage of Esmolol include Bradycardia, Hypotension, Drowsiness, Loss of conciousness.The symptomatic adverse reactions produced by Esmolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Weakness, Dizziness, Irritability, Dyspnea, Necrosis, Hypotension, Diaphoresis, Thrombophlebitis, Paresthesias, Peripheral ischemia, dizziness.
Indications
'Esmolol is primarily indicated in conditions like Adjunct to prevent relapse, Atrial fibrillation, Atrial flutter, Intraoperative tachycardia and/or hypertension, Mild to moderate dementia in alzheimer''s disease, Paroxysmal supraventricular tachycardia, Postoperative tachycardia and/or hypertension, Short-term treatment of supraventricular arrhythmias, Tobacco amblyopia and leber''s optic atrophy.'
Interactions
No data regarding the interactions of Esmolol was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 25°C. Inj (reconstituted soln) Store in refrigerator. Use within 24 hrs if kept at room temperature.
Warnings
It should be use with caution in diabetic patients and patients with kidney or liver disease.
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