Enoximone

Enoximone is a phosphodiesterase inhibitor similar to amrinone, with +ve ionotropic and vasodilator activity. Enoximone is administered intravenosly in the management of heart failure.

Brands
PERFAN
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Imidazol. . The Molecular Weight of Enoximone is 248.30. Its pKa is 10.3.
Contraindications
Enoximone is contraindicated in conditions like Epilepsy,Hypovolaemia.
Effects
The severe or irreversible adverse effects of Enoximone, which give rise to further complications include Hypotension, Hypotension, Tonic-clonic seizures, Arruthmia.Enoximone produces potentially life-threatening effects which include Ventricular tachycardia. which are responsible for the discontinuation of Enoximone therapy.The symptomatic adverse reactions produced by Enoximone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Fever, Abdominal pain, Chills, Local thrombophlebitis, Irritation, Sleep disturbance, Thrombocytopenia, Oliguria, Urinary retention, Pain in upper & lower extremities, Abnormal liver enzyme values.
Indications
Enoximone is primarily indicated in conditions like Acute heart failure.
Interactions
No data regarding the interactions of Enoximone was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
IV Inj, IV Inf Store Below 20°C. Do not Freeze.
Warnings
Blood pressure, heart rate, ECG, fliud and electrolyte status, platelet count and liver function should be monitored during therapy. It should be used with caution in patients with liver or renal disease, hypertrophic cardiomypathy or severe obstructive aortic or pulmonary valvular disease.
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