Eflornithine

Eflornithine (HCl) is an antiprotozoal agent. Eflornithine (HCl) is used in the treatment of African trypanosomiasis and is effective in early and more importantly in late stages of this disease when there is CNS involvement. It acts as an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in the biosynthesis; trypanosomas are more susceptible yo the effect of eflornithine. It also has activity against Pneuocystis carinii.

Brands
DEPILUS EFLOGEN EPILA EPILA
Adult Dose
Dose: 50 mg/kg
Single Dose: 50 (50)
Frequency: As recommended.
Route: IV
Instructions:
Neonatal
Paedriatic
Characteristics
Eflornithine (HCl) is the derivative of Eflornithine. It is of Synthetic origin and belongs to Difluoromethyl Ornithine. . The Molecular Weight of Eflornithine is 236.60.
Contraindications
Eflornithine is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Eflornithine, which give rise to further complications include Anemia, Anemia, Thrombocytopenia, Skin rashes, Leucopenia, Seizures, Irritation, Anemia, Anemia.Eflornithine produces potentially life-threatening effects which include Cardiac Arrest, Cardiac arrest. which are responsible for the discontinuation of Eflornithine therapy.The symptomatic adverse reactions produced by Eflornithine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Vomiting, Alopecia, Anorexia, Diarrhea, Abdominal pain, Asthenia, Facial edema, Folliculitis, Alopecia, dizziness.
Indications
Eflornithine is primarily indicated in conditions like Meningoencephalitic intrypanosoma brucei infection, Sleeping sickness., Trypanosomiasis.
Interactions
No data regarding the interactions of Eflornithine was found.
Interfrence
Increased in Serum Aminotransferase
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 30°C. Do not Freeze. Protect from Sunlight. Inj (reconstituted soln) Store in refrigerator. Do not Freeze. Use within 24 hrs (at 4C) if refrigerated.
Warnings
It should be used with caution in patients with impaired renal function. Dose adjustment is necessary to compensate for reduced excretion of the drug. Other drugs should not be administeredduring infusion with eflornithine. Safety and effectiveness in children have not been established. Avoid Eflornithine getting in your eyes,nose or mouth. Donot wash treated areas for atleast 4 hours. Tell your doctor if you are allergic to it or if you ever had acne.
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