Ceftizoxime (Na)

Ceftizoxime is a third generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Ceftizoxime is a broad spectrum, β lactamase resistant antibiotic effective against a wide range of aerobic and anaerobic gram positive and gram negative bacterias. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftizoxime (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Brands

CEFIZOX CEFIZOX CEFIZOX CEFTIMOX CEFTIMOX TIZOCEF TIZOCEF TIZOCEF CFT CFT CFT ZOTICEF ZOTICEF CEFTROL CEFTROL CEFTROL SYDOCEF SYDOCEF SYDOCEF CEFTIZ CEFTIZ CEFTIZ ZOXI ZOXI ZOXI ZOXCEF ZOXCEF ZOXCEF

Adult Dose

Dose: 1000 to 2000 mg
Single Dose: 1500 (1500)
Frequency: 12 hourly
Route: IM/IV
Instructions:

Neonatal

Dose: 50 mg/kg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: Intramuscular
Instructions:

Paedriatic

Dose: 50 mg/kg
Single Dose: 50 (50)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -

Characteristics

. It is of Semi Synthetic origin and belongs to cephalosporine. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Ceftizoxime (Na) is 405.40. Its pKa is 2.95.

Contraindications

Ceftizoxime (Na) is contraindicated in conditions like Hypersensitivity to any component of product.

Effects

The severe or irreversible adverse effects of Ceftizoxime (Na), which give rise to further complications include Thrombocytopenia, Hypersensitivity reactions, Eosinophilia, Leucopenia, Neutropenia, Thrombocytosis.Ceftizoxime (Na) produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylaxis, Diarrhea. which are responsible for the discontinuation of Ceftizoxime (Na) therapy.The symptomatic adverse reactions produced by Ceftizoxime (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Fever, Rashes, Pruritus, Local reactions, Nausea and vomiting, Elevated alkaline phosphatase, Elevated SGPT & SGOT.

Indications

Ceftizoxime (Na) is primarily indicated in conditions like Bacteremia, Genitourinary tract infections, Intra-abdominal infections, Lower respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, and can also be given in adjunctive therapy as an alternative drug of choice in Bacterial infections, Bone and joint infection, Gonorrhoea, Gynecological infections, Meningitis, Surgical prophylaxis.

Interactions

No data regarding the interactions of Ceftizoxime (Na) was found.

Interfrence

Interference with copper reduction tests for urinary glucose.

Risks

Drug should not be given to patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Inj Store Below 40°C. Protect from Sunlight.

Warnings

Ceftizoxime should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

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