Dolasetron (Mesylate)

Dolasetron (Mesylate) is a specific 5HT-3 antagonist, similar to ondensetron. It block 5HT-3 receptors in the gastrointestinal tract and in the CNS. Dolasetron (Mesylate) is used chiefly in the management of nausea and vomiting induced by cytotoxic drugs during chemotherapy or in post-operative nausea and vomiting.

Brands
AVIFIX
Adult Dose
Dose: 100 mg
Single Dose: 100 (100)
Frequency: As recommended.
Route: PO
Instructions: For Prevention of Cancer Chemotherapy-Induced Nausea and Vomiting: Should be given within one hour before chemotherapy.
Neonatal
Paedriatic
Dose: 1.8 to 100 mg/kh
Single Dose: 51 (50.9)
Frequency: As recommended.
Route: IV
Instructions: Over 2 years of age , with in 1 hour before chemotherapy, for prevention of chemotherapy induce nuas
Characteristics
Dolasetron (Mesylate) also known as Octohydro-3-oxo-2, Octohydro-3-oxo-2, Octohydro-3-oxo-2. . It is of Synthetic origin and belongs to Methanesulfonate. . The Molecular Weight of Dolasetron (Mesylate) is 428.50. Its pKa is 6.4.
Contraindications
Dolasetron (Mesylate) is contraindicated in conditions like Heart disease,Hypersensitivity.
Effects
The symptomatic adverse reactions produced by Dolasetron (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Drowsiness, Fatigue, Diarrhea, Constipation, Abdominal pain, Hot flushes, Abnormal LFT, Hypertension, Symptomatic cardiovascular events, QT prolongation, dizziness, Abnormal LFT.
Indications
Dolasetron (Mesylate) is primarily indicated in conditions like Nausea and vomiting (chemotherapy induced), Nausea and vomiting (prevention), Nausea and vomiting (radiothrapy induced).
Interactions
Dolasetron (Mesylate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDexamethasoneVORICONAZOLEAdditive QTc prolongation may occur.Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
No well documented
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, IV Inj Store Between 20°C-25°C. Protect from Sunlight.
Warnings
It should be used with caution in patients with severe renal failure or severe hepatic failure.
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