DIDIZ DIVIR

Dose: 125 mg
Single Dose: 120 (125)
Frequency: 12 hourly
Route: PO
Instructions: For at less than 60 kg.

Dose: 180 mg/m2
Single Dose: 180 (180)
Frequency: As recommended.
Route: combination with zidovudine in 1-2 divided dose. older than 6th year of age. As single dose or indiv
Instructions:

Didanosine also known as DDI. . It is of Synthetic origin and belongs to Deoxyinosine. . The Molecular Weight of Didanosine is 236.20. Its pKa is 9.13.

Didanosine is contraindicated in conditions like Pancreatitis,Renal failure,Peripheral neuropathy,Liver diseases,Hypersensitivity.

The severe or irreversible adverse effects of Didanosine, which give rise to further complications include Hepatitis, Pancreatitis, Peripheral neuropathy, Myopathy, Retinotoxicity.The symptomatic adverse reactions produced by Didanosine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Anorexia, Diarrhea, Anxiety, Abdominal pain, Rashes, Confusion, Hyperuricemia, Xerostomia, Hepatomegaly, Retinal hyperpigmentation, Lactic acidosis, Hepatic steatosis, Dry eye, Confusion.

Didanosine is primarily indicated in conditions like HIV infection, and can also be given in adjunctive therapy as an alternative drug of choice in HIV encephalopathy, HIV infection in combination with other antiretroviral drugs, Prophylaxis for accidental exposure to HIV.

Didanosine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAllopurinolAllopurinol possibly increases plasma concentration of didanosine.AzathioprineDue to overlapping toxicity profile hematological adverse effects may be observed during their coadministration.ModerateCoadministration should be avoided.Extreme caution and clinical monitoring is advised if they are used together.DapsoneHydroxyureaDidanosine may increase surgeryIndinavir (Sulphate)Interferon Alpha 2bKetoconazoleMoxifloxacinDidanosine contains aluminium and magnesium ion buffering agents which reduce the bioavailability of moxifloxacin.NelfinavirNevirapineOfloxacinRibavirinCoadministration of Ribavirin and didanosine is contraindicated as because exposure to the active metabolite of didanosine are increased. Fatal hepatic failure, as well as peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis have been reported in patients receiving both didanosine and ribavirin.RitonavirSulfapyridineConcurrent use of sulfapyridine with bone marrow depressants may increase the leukopenic or thrombocytopenic effects of these medications.If concurrent use is required, close observation for myelotoxic effects should be considered.Tenofovir DisoproxilConcurrent use increase the effect of Tenofovir Disoproxil.ModerateVORICONAZOLEDidanosine may interfere with the absorption of orally administered voriconazole. Didanosine buffered formulations should be administered at least 2 hours from oral voriconazole administrationZidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Oral Soln (reconstituted) Store at room temperature. Use within 4 hrs if kept at room temperature. Pediatric Oral Soln Store in refrigerator. Use within 30 days if kept at room temperature. Powder for Oral Soln Store at room temperature. Tab Store in a well closed container, at room temperature. Protect from Moisture.

It should be used with caution in patient with impaired renal or hepatic function. Regular checks of liver function are recommended. If liver function deteriorates during treatment then didanosine should be withdrawn. Childrens and adults should be monitored for retinal lesions and didanosine should be withdrawn if they occur.