Desflurane

Desflurane is a volatile halogenated inhalational anaesthetic. Desflurane is a widely used anaesthetic for outpatient surgery because of its rapid onset of action and rapid recovery. It decreases cerebral vascular resistance and cerebral metabolic oxygen consumption. It produces direct skeletal muscle relaxation as well as enhancing the effects of neuromuscular blocking agents.

Brands
Adult Dose
Dose: 0.5 to 1 MAC
Single Dose: 0.75 (0.75)
Frequency: As recommended.
Route: Inh
Instructions: For administration after induction with an intravenous induction agent.
Neonatal
Paedriatic
Characteristics
.
Contraindications
Desflurane is contraindicated in conditions like Ischaemic heart disease,Malignant hyperthermia.
Effects
The severe or irreversible adverse effects of Desflurane, which give rise to further complications include Cough, Laryngospasm, Oxyhemoglobin desaturation.Desflurane produces potentially life-threatening effects which include Malignant hyperpyrexia. which are responsible for the discontinuation of Desflurane therapy.The symptomatic adverse reactions produced by Desflurane are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, dizziness.
Indications
Desflurane is primarily indicated in conditions like Induction and maintenance of anaesthesia, Induction of anaesthesia, Maintenance of anaesthesia.
Interactions
Desflurane is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAtracurium (Besylate)Mivacurium (Cl)Mivacurium (Cl)Pancuronium (Br)Vecuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Increased blood glucose level
Risks
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inhaler Store Below 25°C. Protect from Heat.
Warnings
It should be used with caution in patient with, or at risk from, increased intracranial pressure, coronary artery disease, hypertension, increased heart rate, respiratory, renal or hepatic impairment.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.