Crisantaspase

Crisantaspase is an enzyme asparaginase produced by Erwinia chrysanthemi, which acts as an anti-neoplastic agent. It breaks down the aminonacid L-asparaginase to aspartic acid and ammonia, and interferes with the growth of malignant cells, which unlike most healthy cells, are unable to synthesise L-asparaginase for their metabolism. Crisantaspase is used almost exclusively in acute lymphoblastic leukaemia.

Brands
PERGINASE AMINOPLASMAL® HEPA LEUNASE
Adult Dose
Dose: 20 IU/m2
Single Dose: 20 (20)
Frequency: As recommended.
Route: IV
Instructions: 4.8hourly
Neonatal
Paedriatic
Dose: 600 units/kg
Single Dose: 600 (600)
Frequency: As recommended.
Route: I/M
Instructions:
Characteristics
Crisantaspase also known as Asparaginase, Asparaginase. . It is of Natural origin and belongs to asparanginare. . The Molecular Weight of Crisantaspase is 130000.00. Its pKa is 8.5.
Contraindications
Crisantaspase is contraindicated in conditions like Hypersensitivity,Pregnancy.
Effects
The severe or irreversible adverse effects of Crisantaspase, which give rise to further complications include Hepatotoxicity, Coma, Hemorrhage, Hepatotoxicity, Thrombosis, Stupor, Tremors, Hypermylasia, Hemorrhagic pancreatitis.Crisantaspase produces potentially life-threatening effects which include Hypotension, Bronchospasm, Bronchospasm, Anaphylaxis, Laryngeal edema, Urticaria. which are responsible for the discontinuation of Crisantaspase therapy.The symptomatic adverse reactions produced by Crisantaspase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Drowsiness, Fatigue, Nausea, Vomiting, Fever, Abdominal pain, Confusion, Hyperglycemia, Increased serum bilirubin, Increased cholestrol, Hepatomegaly, Malabsorption, Confusion.
Indications
'Crisantaspase is primarily indicated in conditions like Acute leukemia, Acute lymphocytic leukemia, Hypersensitivity of E.Coli, Lymphoblastic lymphoma, Lymphoid malgnancies, Non-hodgkin''s lymphoma, Non-hodgkin''s lymphoma.'
Interactions
No data regarding the interactions of Crisantaspase was found.
Interfrence
Thyroid Function Test
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (reconstituted soln) Store at room temperature. Use within 15 min if kept at room temperature. Powder for Inj Store in refrigerator.
Warnings
Therapy should only be given where there are adequate facilities for ventilation and monitoring.
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