Ciprofibrate

Ciprofibrate is an oral lipid regulating, a fibric acid derivative with actions and uses similar to those of bezafibrate. Ciprofibrate is used in the treatment of type II a, II b, type III , and type IV hyperlipidemias.


Brands
Adult Dose
Dose: 100 mg
Single Dose: 100 (100)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Propanoic Acid. . The Molecular Weight of Ciprofibrate is 289.20. Its pKa is 4.6.
Contraindications
Ciprofibrate is contraindicated in conditions like Renal impairment,Hepatic impairment.
Effects
Ciprofibrate produces potentially life-threatening effects which include Rhabdomyolysis, Myositis. which are responsible for the discontinuation of Ciprofibrate therapy.The symptomatic adverse reactions produced by Ciprofibrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vertigo, Tiredness, Headache, Drowsiness, Nausea, Vomiting, Diarrhea, Skin rashes, Impotence, Hair loss, Increased intracranial pressure.
Indications
Ciprofibrate is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemias of type IIa, IIb, III and IV in patients who have not responded adequately to diet., Hyperlipidemia, Hypertriglyceridaemia.
Interactions
Ciprofibrate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCerivastatin SodiumCerivastatin sodium causes additive toxicity with CiprofibrateCholestyramineSimvastatinWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Liver Function Test (LFT)
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store at room temperature.
Warnings
Clofibrate should not be given to patients with severe liver or kidney impairment, primary biliary cirrhosis, gallstone or gallbladder disorder or hypoalbuminaemic state.
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