Ceftazidime

Ceftazidime is a third-generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Ceftazidime is a broad spectrum, β lactam antibiotic, effective against gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. Ceftazidime is used in the treatment of biliary tract infection. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Ceftazidime is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Brands
TAZIDIME TAZIDIME TAZIDIME KEFADIM KEFADIM KEFADIM TEZDA TEZDA XIDIM XIDIM SATSIN SATSIN UTAZID UTAZID UTAZID FORTAZIM FORTAZIM FORTAZIM CEFCOM CEFCOM CEFCOM CEPLO CEPLO CEPLO DIMICEF DIMICEF EPOCEF EPOCEF EPOCEF PENTUM PENTUM PENTUM FORTUM FORTUM FORTUM PATHONIL PATHONIL PATHONIL SEFTA SEFTA SEFTA DAY FORT DAY FORT DAY FORT INJEX INJEX INJEX MITAZ MITAZ MITAZ PAR-FECTION PAR-FECTION PAR-FECTION CEFTACIN CEFTACIN CEFTACIN CEFZIMED CEFZIMED BIOMED BIOMED BIOMED CEFAZID CEFAZID NEUTIM NEUTIM NEUTIM N-DIME N-DIME N-DIME CEFOSEL CEFOSEL CEFOSEL EVOZID EVOZID EVOZID CEFTAZ CEFTAZ CEFTAZ FOZIDIM FOZIDIM FOZIDIM FORZID FORZID GLOSSON GLOSSON GLOSSON BREEFORT BREEFORT BREEFORT NIVADOR NIVADOR NIVADOR CEFWELL CEFWELL CEFWELL FITEM FITEM FITEM CEZAF CEZAF CEZAF CIZIDIM CIZIDIM CIZIDIM ZATRON ZATRON ZATRON TIZID TIZID TIZID ZITUM ZITUM ZITUM ZIPENTA ZIPENTA ZIPENTA ULTRAZID ULTRAZID ULTRAZID FORDEME FORDEME FORDEME BLOTAZ BLOTAZ BLOTAZ CEFAZ CEFAZ CEFAZ CEFODIME CEFODIME BACTAZIME BACTAZIME BACTAZIME FAZIM FAZIM FAZIM ZORTUM ZORTUM ZORTUM VALOZID VALOZID VALOZID ELEKT ELEKT FEZADIM FEZADIM FEZADIM XTRADIM XTRADIM CAYZON CAYZON CAYZON EPHTUM EPHTUM EPHTUM XTRAZID XTRAZID XTRAZID FORTAMED FORTAMED FORTAMED ROBICEF ROBICEF ROBICEF MORTAM MORTAM MORTAM BIOZID BIOZID BIOZID IPRA-DIME IPRA-DIME IPRA-DIME CEFTERA CEFTERA FORAM FORAM FORAM Z.D Z.D Z.D T-ZD T-ZD QISDIM QISDIM KAHARA KAHARA KAHARA TAZECEF TAZECEF TAZECEF FORSIN FORSIN FORSIN F-NOV F-NOV F-NOV FRESZID FRESZID TINADEME TINADEME GRATOX GRATOX GRATIN GRATIN EFTAX EFTAX EFTAX HARIDONE HARIDONE HARIDONE TAZOBID TAZOBID TAZOBID JIZDIME JIZDIME JIZDIME TIMS TIMS ZAYDIME ZAYDIME ZAYDIME SLUSH SLUSH CEFAROWN CEFAROWN GENDIME GENDIME GENDIME CETADINE CETADINE CETADINE LIFZIM LIFZIM LIFZIM ASTEDIME AVETAZ NEUDIME NEUDIME PARADIME PARADIME
Adult Dose
Dose: 1 to 6 g
Single Dose: 3.5 (3.5)
Frequency: 8 hourly
Route: IV,IM
Instructions: or twice daily if needed.
Neonatal
Dose: 25 to 60 mg/kg
Single Dose: 42 (42.5)
Frequency: 8 hourly
Route: IV
Instructions: In 2 divided doses
Paedriatic
Dose: 30 to 100 mg/kg
Single Dose: 65 (65)
Frequency: As recommended.
Route: IV
Instructions: In two to three divided doses
Characteristics
Ceftazidime Pentahydrate, Ceftazidime Pentahydrate are the derivatives of Ceftazidime. It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Ceftazidime is 636.70. Its pKa is 1.8, 2.7, 4.1.
Contraindications
Ceftazidime is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Ceftazidime, which give rise to further complications include Rashes, Thrombocytopenia, Stevens johnson syndrome, Hypersensitivity reactions, Transient leucopenia, Neutropenia, Lymphocytosis, Elevation in serum creatinine, Bleeding, Increased blood urea nitrogen, Superinfection, Candidiasis, Breathing difficulty, Hives, Myoclonia.Ceftazidime produces potentially life-threatening effects which include Pseudomembranous colitis, Encephalitis, Anaphylactic reactions, Epilepsy. which are responsible for the discontinuation of Ceftazidime therapy.The signs and symptoms that are produced after the acute overdosage of Ceftazidime include Coma, Seizures, Encephalopathy.The symptomatic adverse reactions produced by Ceftazidime are more or less tolerable and if they become severe, they can be treated symptomatically, these include Inflammation, Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Pruritus, Pain, Colitis, Vaginitis, Skin RashX, Tremor, Phlebitis, Thrombophlebitis, Paresthesias, Stomachache, Erythema multiforme.
Indications
Ceftazidime is primarily indicated in conditions like Bacteremia, Bacterial infections, Biliary tract infections, Bone and joints infections, Diverticulitis, Endometritis, Ent infections, GI infections, Gynecological infections, Intra-abdominal infections, Lower respiratory tract infections, Lung abscess, Meningitis, Osteomyelitis, Pelvic infections, Peritonitis, Pneumonia, Pophylaxis of acute renal transplant rejection, Pseudomonal lung infection in cystic fibrosis, Septicaemia, Skin infections, Soft tissue infections, Urinary tract infection, UTIs and less serious infections.
Interactions
No data regarding the interactions of Ceftazidime was found.
Interfrence
Positive Coombs test which interfere with cross-matching of blood. Copper reduction tests for glycosuria.
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Dry Powder for Inj Store Below 40°C. Protect from Sunlight. Inj (reconstituted soln) Store at room temperature or refrigerator. Use within 7 days if refrigerated and within 18-24 hrs if kept at room temperature.
Warnings
Ceftazidime should be used with caution in patients with impaired kidney or liver function. Appropriate measures should be taken if secondary infection occurs. Use with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma). Caution is required in patients with history of hypersensitivity to ceftazidime, cephalosporins, penicillins or other drugs especially those with previous hypersensitivity reactions to penicillins. Discontinue treatment if an allergic reaction occurs. Emergency procedures may be required in such cases. Concurrent use with nephrotoxic drugs e.g., aminoglycosides, potent diuretics, may affect renal function. Neurological sequelae have been reported when dose is not reduced in patients with renal impairment. Prolonged use may develop resistance during therapy. When ceftazidime and chloramphenicol is administered concurrently, the possibility of antagonism should be considered.
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