Botulinum Toxin Type A

Botulinum Toxin Type A is an exotoxin produced by germinating spores and growing cells of Clostridium botulinum. There are seven immunologically distinct types (A-G). Type A is one of the most powerful poisons known. It binds to presynaptic terminals of the central nervous system and inhibits the calcium-ion mediated release of acetylcholine at the motor nerve terminals, leading to flaccid paralysis of the affected muscles. Paralysis persists for about 2-3 months (until new nerve terminals form). Botulinum Toxin Type A is used in the treatment of hemifacial spasm, blepharospasm, spasmodic torticollis, and lower limb spasticity in children with cerebral palsy.

Brands

BOTOX

Adult Dose

Dose: 50 units
Single Dose: 50 (50)
Frequency: As recommended.
Route: ID
Instructions: Dose for Hyperhidrosis: sual dose should be injected intradermally in 0.1 to 0.2 mL aliquots to each axilla distributed evenly in multiple sites (10 to 15) 1 to 2 cm apart.

Neonatal

Paedriatic

Characteristics

. It is of Natural origin and belongs to protien. . The Molecular Weight of Botulinum Toxin Type A is 150000.00.

Contraindications

Botulinum Toxin Type A is contraindicated in conditions like Myasthenia gravis,Pregnancy,Immunocompromised patient,Bleeding diathesis,Breast feeding.

Effects

The severe or irreversible adverse effects of Botulinum Toxin Type A, which give rise to further complications include Vertical misalignment of eyes.Botulinum Toxin Type A produces potentially life-threatening effects which include Laryngeal edema, Aspiration of body fluid. which are responsible for the discontinuation of Botulinum Toxin Type A therapy.The signs and symptoms that are produced after the acute overdosage of Botulinum Toxin Type A include Dysphagia, Focal muscles weakness.The symptomatic adverse reactions produced by Botulinum Toxin Type A are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diplopia, Dysphagia, Swallowing difficulties, Neck weakness, Lower facial weakness, Ectropion.

Indications

Botulinum Toxin Type A is primarily indicated in conditions like Anal fissure, Focal or segmental limbdystonia, Hemifacial spasm, Idiopathic blepharospasm, Muscular spasm, Oromandibular dystonia, Spasmotic dysphonia.

Interactions

No data regarding the interactions of Botulinum Toxin Type A was found.

Interfrence

Risks

Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

IM Inj Store in refrigerator.

Warnings

Its injection especially those into the neck, should be made with great care to avoid unintended paralysis, deep or misplaced injection should be avoided. Potential for anaphylaxis

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