Atovaquone

Atovaquone is an anprotozoal, and a highly lipophilic analog of ubiquinone. It interferes with mitochondrial electron transport and related processes in suseptible malaria parasites. It has potent activity against blood stages of plasmodia, tachyzoites and cyst formsof T.gondii, the fungus P.carinii, and Babesia species. Atovaqunone is used with a biguanide for the treatment of malariato obtain optimal clinical results and avoid emergence of drug-resultant plasmodial strains.

Brands
PROQON PROQON PROQON PROQON
Adult Dose
Dose: 750 mg
Single Dose: 750 (750)
Frequency: 12 hourly
Route: PO
Instructions: This dose is for treatment of mild-moderate PCP(pneumocystis carini pneumonia): 750mg or 5ml two times daily taken with meal.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Naphthalenedione. It belongs to Antiprotozoal pharmacological group.The Molecular Weight of Atovaquone is 366.80. Its pKa is not known.
Contraindications
Atovaquone is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Atovaquone, which give rise to further complications include Maculopapular rash.The symptomatic adverse reactions produced by Atovaquone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Fever, Insomnia, Rashes, Asthenia, Anemia.
Indications
Atovaquone is primarily indicated in conditions like Pneumocystis carinii pneumonia, Prophylaxis of acid aspiration in obstetric patients, and can also be given in adjunctive therapy as an alternative drug of choice in Acute toxoplasmic encephalitis, Malaria, Prophylaxis of p-carinii pneumonia.
Interactions
No data regarding the interactions of Atovaquone was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oral Susp Store Between 15°C-25°C. Do not Freeze. Tab Store at room temperature, Below 30°C.
Warnings
Atovaquone should be used with caution in initial diarrhoea and difficulty in taking with food may reduce absorption (and require alternative therapy); other causes of pulmonary disease should be saught and treated; elderly; hepatic and renal impairment; avoid breast-feeding.
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