Apraclonidine (HCl)

Apraclonidine (HCl) is an alpha-2 adrenoceptor agonist, a derivative of clonidine. It reduces the secretions of aqueous humour in the anterior chamber of the eye. Therefore, Apraclonidine (HCl) is used to control intra-ocular pressure (IOP), following laser surgery to the eye. Apraclonidine (HCl) is also used to delay laser treatment or surgery for glaucoma, in patients not adequately controlled by another drug.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Benzenediamine. . The Molecular Weight of Apraclonidine (HCl) is 281.58. Its pKa is 1.16, 9.22.
Contraindications
Apraclonidine (HCl) is contraindicated in conditions like Hypersensitivity,CNS depression.
Effects
The severe or irreversible adverse effects of Apraclonidine (HCl), which give rise to further complications include Edema of lids, Foreign body sensation.Apraclonidine (HCl) produces potentially life-threatening effects which include Hypertensive crises, Stroke. which are responsible for the discontinuation of Apraclonidine (HCl) therapy.The signs and symptoms that are produced after the acute overdosage of Apraclonidine (HCl) include Bradycardia, Hypotension, Vomiting, Apnea, Coma, Seizures, Dry mouth, Hypothermia, Irritability, Lethargy, Pallor, Sedation, Somnolence, Diminished reflexes, Conduction disturbances, Transient hypertension, Asthenia, Arrhythmias.The symptomatic adverse reactions produced by Apraclonidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Blurred vision, Pruritus, Pain, Itching, Malaise, Facial edema, Chest pain, Conjunctivitis, Asthma, Dryness of eye, Discomfort, Hyperemia, Tearing, Foreign body sensation, Keratitis, Belching.
Indications
Apraclonidine (HCl) is primarily indicated in conditions like Glucoma, Post-operative elevation of intraocular pressure.
Interactions
No data regarding the interactions of Apraclonidine (HCl) was found.
Interfrence
Risks
Drug should not be given to Paediatrics, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Eye Soln Store Below 25°C. Protect from Sunlight.
Warnings
It should be used with care in patient with severe cardiovascular disease including hypertension, in patient with a history of vasovagal attacks and in depressed patient.
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