Alglucerase

Alglucerase is a modified form of human placental enzyme (β-glucocerebrosidase), and a monomeric glycoprotien containing 497 amino acids with glycosylation. Alglucerase is used as enzyme replacement therapy.

Brands
Adult Dose
Neonatal
Paedriatic
Characteristics
. It is of Natural origin and belongs to Protien. . The Molecular Weight of Alglucerase is 59300.00. Its pKa is 7.3 - 7.8.
Contraindications
Alglucerase is contraindicated in conditions like Prostatic cancer,Skeletal disease,Allergy to serum albumin.
Effects
The severe or irreversible adverse effects of Alglucerase, which give rise to further complications include Upper airway inflammation, Sense of laryngeal constriction.The symptomatic adverse reactions produced by Alglucerase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Vomiting, Fever, Abdominal cramps, Chills, Urticaria, Pruritus, Allergic reactions, Flushing, Cough, Virilization, Angioedema, Chest tightness, Discomfort, Reaction at injection site.
Indications
Alglucerase is primarily indicated in conditions like Gauchers disease (type I).
Interactions
No data regarding the interactions of Alglucerase was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze. Protect from Sunlight.
Warnings
Caution is required in patient who have exhibited sign of hypersenitivity, if hypersensitivity reaction occurs the drug should be discontinued. It is prepared from human placenta therefore carries a risk of transmission of infection. It should be used with caution in patient with androgen-sensitive malignancies. It is classified as pregnancy cateogry C. It should be used with caution during pregnancy and only when the benefit outweighs the risk.
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