Para-Amino Salicylic Acid

Para-Amino Salicylic Acid is used in combination for the treatment of tuberculosis, when other more potent drugs cannot be used.

Brands
P.A.S
Adult Dose
Dose: 10 to 12 g
Single Dose: 11 (11)
Frequency: As recommended.
Route: PO
Instructions: Daily in 2-3 div.doses
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin and belongs to Amino Hydroxybenzoic Acid. . The Molecular Weight of Para-Amino Salicylic Acid is 211.20. Its pKa is 3.2.
Contraindications
Para-Amino Salicylic Acid is contraindicated in conditions like Renal diseases,Hypersensitivity.
Effects
The severe or irreversible adverse effects of Para-Amino Salicylic Acid, which give rise to further complications include Rashes, Fever, Hepatotoxicity, Conjunctivitis, Eosinophilia, Pruritis, Hypersensitivity reactions, Pulmonary infiltration.Para-Amino Salicylic Acid produces potentially life-threatening effects which include Hepatotoxicity, Necrosis, Fatty vacuolization, Granular degeneration. which are responsible for the discontinuation of Para-Amino Salicylic Acid therapy.The symptomatic adverse reactions produced by Para-Amino Salicylic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Diarrhea, Abdominal cramps, GI upset, Goiter, Macrocytic anemia.
Indications
Para-Amino Salicylic Acid is primarily indicated in conditions like Multi-drug resistance tuberculosis.
Interactions
Para-Amino Salicylic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementProbenecidRifabutinRifampicin These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Plasma and Serum Tests for Corticosteroids
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab Store in a well closed container, at room temperature, Below 30°C. Protect from Sunlight.
Warnings
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