Cefotetan

Cefotetan is a second generation, semisynthetic, β lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefotetan is a broad spectrum antibiotic effective against a wide range of gram positive, gram negative and anaerobic bacterias. Cefotetan is less effective against gram positive bacterias than first generation drugs. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefotetan is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Brands

Adult Dose

Dose: 14.28 mg/kg
Single Dose: 14 (14.28)
Frequency: 12 hourly
Route: IM
Instructions: -

Neonatal

Dose: 10 to 30 mg/kg
Single Dose: 20 (20)
Frequency: 12 hourly
Route: Intravenous
Instructions: Dose for children above 6 months

Paedriatic

Dose: 10 to 30 mg/kg
Single Dose: 20 (20)
Frequency: 12 hourly
Route: Intra Venous
Instructions: -

Characteristics

. It is of Semi Synthetic origin and belongs to Cephamycin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Cefotetan is 619.56. Its pKa is 2.1.

Contraindications

Cefotetan is contraindicated in conditions like Meningitis.

Effects

The severe or irreversible adverse effects of Cefotetan, which give rise to further complications include Rashes, Fever, Urticaria, Thrombocytopenia, Eosinophilia, Candidal superinfection, Angioedema, Erythema, Dermatitis, Leucopenia, Increased prothrombin time, Positive coombs test, Abnormal LFT.The symptomatic adverse reactions produced by Cefotetan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Phlebitis, Nausea and vomiting.

Indications

Cefotetan is primarily indicated in conditions like Dental infections, Ent infections, Gonorrhoea, Intra-abdominal infections, Obstetric and gynaecological infections, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI.

Interactions

Cefotetan is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholProbenecidWarfarin (Na)Cefotetan may enhance the anticoagulant effect of Warfarin. ModerateMonitor for increased evidence of bleeding if Cefotetan is used concomitant with Warfarin. Cephalosporins that have an NMTT side chain in their chemical structure may pose the greater risk of interaction. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Interfrence

Clinitest copper-reduction method for determining glucose concentration in urine. Alkaline Picrate Assay.

Risks

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Storage

Inj (reconstituted soln) Store at room temperature or refrigerator. Protect from Sunlight. Use within 96 hrs (at 5C ) if refrigerated and within 24 hrs if kept at room temperature. Powder for Inj Store Below 25°C. Protect from Sunlight. Prefrozen Inj Store Below -20°C. Thawed Store at room temperature or refrigerator. Use within 21 days (at 5C ) if refrigerated and within 48 hrs if kept at room temperature.

Warnings

Cefotetan should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

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