Cefixime

Cefixime is a third generation semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefixime is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin, gonorrhea, otitis media, and urinary tract infections. Administered orally. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefixime is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Brands
LINASPAN LINASPAN Y-FIX Y-FIX RAYCEF RAYCEF ALBROCEF ALBROCEF BENIFIX BENIFIX KAKAXIME KAKAXIME KAKAXIME LINZIM LINZIM LINZIM LINZIM CEBOSH CEBOSH CEBOSH CEBOSH CEBOSH CEBOSH CEFSPAN CEFSPAN CEFSPAN CEF-OD CEF-OD D-ZIME VIXIME VIXIME ELIXIME ELIXIME ELIXIME CEFIMAX CEFIMAX CEFIMAX EPOFIX EPOFIX EPOFIX PRIXIME FEDIXIME FEDIXIME FEDIXIME FIXVAL FIXVAL FIXVAL WELXIME WELXIME WELXIME PLUS MAXOPHINE MAXOPHINE MAXOPHINE MAXOPHINE FLEXERIL FLEXERIL FLEXERIL SEPTIPAN DS SEPTIPAN SEPTIPAN CEFIGET CEFIGET CEFIGET CEFIGET CEFIGET FLOZID FLOZID CEWEL CEFIM CEFIM CEFIM CEFIM CEFIM MIXEL MIXEL CEFAZON CEFAZON TYCEF TYCEF TYCEF KAYFIX KAYFIX KAYFIX KAYFIX DS ICEF ICEF ICEF MAXPAN MAXPAN MAXPAN MAXPAN MAXPAN KEFAZYME PAEDIATRIC KEFAZYME TYSEN TYSEN TYSEN TYSEN IDEXIME IDEXIME IDEXIME POMEX MAXIMA MAXIMA MAXIMA MAXIMA MAXIMA MAXIMA ORPASE ORPASE ORPASE LIBROXIME LIBROXIME LIBROXIME CIMONIL CIMONIL GENIXIME DS BACTIRID BACTIRID BACTIRID BACTIRID SUPRIN SUREXIME SUREXIME SPRIL SPRIL SPRIL CEFEXOL CEFEXOL CEFEXOL NEFIXIM NEFIXIM NEFIXIM ORTAZIM OBPAN NENXIME NENXIME SPANIX SPANIX SPANIX CEFITOL CEFITOL CEFITOL FORTE CEFLOREX CEFLOREX CEFLOREX EVOFIX EVOFIX PROCEF PROCEF XIMCEF XIMCEF SNAPCEF SNAPCEF PHARXIME PHARXIME TINOCEF TINOCEF TINOCEF TINOCEF ARCOFIX ARCOFIX CEFAMAX CEFAMAX CEFAMAX CEFAMAX CEFTO CEFTO CEFTO AMBER AMBER AMBER CEFTAS AEROCEF AEROCEF AEROCEF SUPRACEF SUPRACEF SUPRACEF BEXACIM BEXACIM CARICEF CARICEF CARICEF CARICEF CARICEF CARICEF CARICEF CARICEF AG-FIX AG-FIX OMIXIM OMIXIM OMIXIM MAGNETT MAGNETT MAGNETT MAGNETT XIVAL XIVAL XIVAL XIVAL ISOCEF ISOCEF ISOCEF ISOCEF SEAXIM SEAXIM SEAXIM SEAXIM DUET DUET FIXIME CAPSULE FIXITIL-T FIXITIL-T FIXITIL FIXITIL FIXITIL SWICEF SWICEF SWICEF CEFIX CEFIX CEFIX CEFIX CEFIX SECURE CAP & SUSP SECURE CAP & SUSP SECURE CAP & SUSP SECURE CAP & SUSP SECURE CAP & SUSP CEFORAL-3 CEFORAL-3 CEFKAN WAYBAC VENCEF VENCEF VENCEF SUPERIXIME SUPERIXIME SUPERIXIME DS CEXIME CEXIME AKSOXIME AKSOXIME AKSOXIME AKSOXIME AKSOXIME SIVAROL SIVAROL SIVAROL SIVAROL VANIL VANIL VANIL VANIL VANIL VANIL ZAXIME ZAXIME DELSIXIME DELSIXIME XIM XIM ENGCEF ENGCEF SUNCEF SUNCEF SUNCEF MEFIX MEFIX MYCEF MYCEF MYCAF FORTE DRY FINEX FINEX FINEX ZYLOFIXIM ZYLOFIXIM F-XIME F-XIME CESEF CESEF CESEF VALDIXIME VALDIXIME REYAN REYAN SOXIME SOXIME SOXIME SOXIME SOXIME TAMCEF TAMCEF TAMCEF TAMCEF IMAX ESPAN IMAX DS ZLOXPAN ZOLOXPAN ZOLOXPAN CEFKAR CEFKAR WIZY WIZY WIZY WIZY KEFXIM CEFACEF CEFACEF K-ZIM K-ZIM K-ZIM EXIM EXIM EXIM SCAVIA-DS SCAVIA SCAVIA SCAVIA MEDISPAN MEDISPAN CEFASK CEFASK NIFIM NIFIM NIFIM ZIFI ZIFI MEGAXIM MEGAXIM MEGAXIM CEFISCOT CEFISCOT CEFISCOT CEFISCOT BIOZIL BIOZIL BIOZIL CEFAIM KAMCEF FORTE KAMCEF KAMCEF NAVEXIM NAVEXIM NAVEXIM GENIXIME GENIXIME BESTAR BESTAR BESTAR CIXIM CIXIM CIXIM CILICEF CILICEF FORTE ZYACEF ZYACEF TAXOMIC TAXOMIC TAXOMIC SANXIM MEFIXIM MEFIXIM MEFIXIM MEFIXIM EVERXIM EVERXIM EVERXIM FORTE MEDIXIM MEDIXIM MEDIXIM MEDIXIM RUTEX RUTEX RUTEX DISPEL DISPEL MEGAZIME MEGAZIME MEGAZIME C-SPAN C-SPAN BLEVO BLEVO BLEVO BLEVO VEFIXIM VEFIXIM SAVIXIM SAVIXIM SAVIXIM AFIXIME AFIXIM BS-CEF BS-CEF BS-CEF BS-CEF BS-CEF REFSPAN REFSPAN REFSPAN MAXIM MAXIM VIMACEF VIMACEF VIMACEF FIXOMYCIN XIMYAN XIMYAN XIMYAN D.SUR-CEF D.SUR-CEF D.SUR-CEF VG-SPAN VG-SPAN VG-SPAN GLIXIM GLIXIM GLIXIM GLIXIM GLIXIM ZIXIM ZIXIM ZIXIM IF-TAR IF-TAR IF-TAR DANXIME DANXIME FEMCEF FEMCEF FEMCEF VASIX VASIX SPECTRACEF SPECTRACEF SPECTRACEF SPECTRACEF ENFEXIA ENFEXIA ENFEXIA FIXIL FIXIL FIXIL REFIXIME REFIXIME ZEECAM ZEECAM FLIZ FLIZ GENMAX GENMAX VIOXIME VIOXIME SYNOCEF SYNOCEF SYNOCEF CICLOXAL CICLOXAL CICLOXAL CEFSEL CEFSEL CEFSEL DS GYALA GYALA GYALA GYALA DS AKURATE AKURATE AKURATE MEDIXIME MEDIXIME WAYBACK WAYBACK WAYBACK FEXIMAK FIXIMAK FIXIMAK QUREX FIXIRIN FIXIRIN ABIFIX ABIFIX OTTOMAX OTTOMAX OTTOMAX OTTOMAX EFICAZ EFICAZ EFICAZ MED-SPAN MED-SPAN WEXIME WEXIME WEXIME CUTEXIA CUTEXIA CUTEXIM CUTEXIM CEFIDERM CEFIDERM CEFIDERM CEFINE CEFINE TRIBAN TRIBAN TRIBAN ZANXIM ZANXIM ZANXIM HEFIXIM HEFIXIM VFIX DS EFIX EFIX VFIX VFIX VFIX CEFABEN CEFABEN CARAZIME CARAZIME CARAZIME CARAZIME SALLAR SALLAR SALLAR M-SPAN M-SPAN M-SPAN EPAN EPAN EPAN EPAN PANXIME PANXIME RAFIX RAFIX RAFIX RAFIX MIXCEF MIXCEF MAXGARD MAXGARD MAXGARD CEFIXMA-DS CEFIXMA CEFIXMA ROGXIME DS ROGXIME ROGXIME CEFGEN CEFGEN CEFGEN ZUMAX ZUMAX ZUMAX CEFIWAN CEFIWAN CEFIWAN HUDIXIME HUDIXIME HUDIXIME CEFICURE CEFICURE CEFICURE CEFICURE CEFICURE AMXIM AMXIM AMXIM AMXIM XECXIM SALFIX CEFIXUN ZE-XIM ZE-XIM ZE-XIM F-SAF F-SAF F-SAF F-SAF PLUS ZINZIN ZINZIN ZINZIN ARIXIME ARIXIME ARIXIME ARIXIME ARIXIME ASTEXIM ASTEXIM ASTEXIM ASTEXIM DEXIME DEXIME DEXIME SPORZIM SPORZIM XIMEX DS ZIXOFIN ZIXOFIN ENTARIS ENTARIS SIMIK SIMIK SIMIK SMIK XIM-STAR XIM-STAR XIM-STAR QUREX QUREX DS CEFIRANT CEFIRANT CEFIRANT MACXIME MACXIME MACXIME CMILE CMILE CMILE AVECOL AVECOL AVECOL AVECOL CREXIME CREXIME CREXIME CESAVE CESAVE CESAVE OD-XIME OD-XIME ZIAC ZIAC ZIAC XIMBACT XIMBACT XIMBACT XIMBACT XIMBACT XIMBACT CEFIPRAY CEFIPRAY CEFIPRAY CEFIPRAY CEFIPRAY ZEXIN ZEXIN EXIME EXIME EXIME WARAXIM WARAXIM WARAXIM STLICEF STLICEF STLICEF WINOCEF WINOCEF SERVE SERVE SERVE SERVE O-XIME O-XIME O-XIME AGROFIX AGROFIX AGROFIX AGROFIX AGROFIX
Adult Dose
Dose: 200 to 400 mg
Single Dose: 300 (300)
Frequency: 24 hourly
Route: PO
Instructions: Dose vary according to indication.
Neonatal
Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 4 mg/kg
Single Dose: 4 (4)
Frequency: 12 hourly
Route: Oral
Instructions: It may be given once a day.
Characteristics
Cefixime Trihydrate is the derivative of Cefixime. It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-3rd Gen pharmacological group.The Molecular Weight of Cefixime is 453.40. Its pKa is 2-2.5.
Contraindications
Cefixime is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Cefixime, which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Thrombophlebitis, Leucopenia, Seizures, Vaginitis.The symptomatic adverse reactions produced by Cefixime are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Nausea, Vomiting, Anorexia, Diarrhea, Abdominal pain, Urticaria, Pruritus, Dyspepsia, Hypersensitivity, Increased intracranial pressure, Xerostomia, Pain at injection site.
Indications
Cefixime is primarily indicated in conditions like Bronchitis, Cardiopulmonary resuscitation, Gonorrhoea, Otitis media, Pharyngitis, Pneumonia, Respiratory tract infections, Uncomplicated UTIs, and can also be given in adjunctive therapy as an alternative drug of choice in Gonococcal urethritis, Typhoid.
Interactions
No data regarding the interactions of Cefixime was found.
Interfrence
False +ve Coombs Test FAlse +ve reaction for Urinary glucose with Benedicts, Fehlings or CuSO4 tes tablest.
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Susp Store at room temperature. Protect from Sunlight and Moisture.
Warnings
Persons allergic to penicillin-type antibiotics should use this medication with caution. An allergy may exist to this as well. This drug should be used only if clearly needed during pregnancy or lactation. Cefixime should be discontinued if diarrhea is severe.
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