Polidocanol

Polidocanol is a non-ionic surfactant, used as a sclerosing agent primarily used in the treatment of uncomplicated Spider veins and Reticular Veins.


Adult Dose
Dose: 0.1 to 0.3 ml
Single Dose: 0.2 (0.2)
Frequency: As recommended.
Route: inj
Instructions: the volume per injecton should not be more than 10ml . For Spider veins use 0.5% solution and for reticular veins use 1% solution. Apply gentle pressure to prevent vein rupture. Wear Compression stockings or support Hose on treated legs continuously for 2-3days and for 5-7 days after treatment of spider veins and _x000D_reticular veins respectively. Advise patient to walk for 15-20 minutes daily for few days. Advise patient to avoid heavy _x000D_excercise, sunbathing, long plane flights and hot bath or sauna.
Neonatal
Paedriatic
Characteristics
belongs to Non-ionic Detergent. It belongs to sclerosing agent pharmacological group on the basis of mechanism of action. The Molecular Weight of Polidocanol is 600.00. It is weakly acidic drug.
Contraindications
Polidocanol is contraindicated in conditions like Thromboembolism,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Polidocanol, which give rise to further complications include Pulmonary embolism, Paresthesia, Dizziness, Loss of consciousness.Polidocanol produces potentially life-threatening effects which include Anaphylactic shock, Syncope, Cardiac Arrest, Dyspnea, Vaso-vagal attacks, Asthma, Angioedema, cerebrovascular accident, Circulatory collapse, Reversible ischemic neurological deficit, deep vein thrombosis. which are responsible for the discontinuation of Polidocanol therapy.The signs and symptoms that are produced after the acute overdosage of Polidocanol include Necrosis.The symptomatic adverse reactions produced by Polidocanol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Necrosis, Pruritus, Pain, Dermatitis, Hot flushes, Pyrexia, Injection site reactions, Injection site hematoma, nerve injury, skin hyperpigmentation, injection site discoloration, injection site pain, injection site pruritus, ijection site warmth, neovascularisation.
Indications
Polidocanol is primarily indicated in conditions like Oesophageal varices, Varicose veins.
Interactions
No data regarding the interactions of Polidocanol was found.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Between 15°C-30°C.
Warnings
Donot inject polidocanol intra-perivascularly as it can cause pain. Donot inject polidocanol intra-arterially as it can cause necrosis, ischemia,gangerene. Use personal protective equipment. Evacuate personnel to safe areas. Should be use with caution in patients history of allergy and observe patients for anaphylaxis polidocanol should not be used during pregnancy
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