Cefamandole (Na)

Cefamandole is a second generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Cefamandole is used to treat a large variety of bacterial infections, Cefamandole (Na) is less effective against gram positive bacteria than first generation drugs. Cefamandole (Na) is usually given for surgical infection prophylaxis. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefamandole (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.

Brands
KEFADOL
Adult Dose
Dose: 500 to 2000 mg
Single Dose: 1200 (1250)
Frequency: 8 hourly
Route: IV,IM
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 16.66 to 50 mg/kg
Single Dose: 33 (33.33)
Frequency: 8 hourly
Route: Intra Muscular
Instructions: -
Characteristics
. It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-2nd Gen pharmacological group.The Molecular Weight of Cefamandole (Na) is 512.50. Its pKa is 2.46.
Contraindications
Cefamandole (Na) is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Cefamandole (Na), which give rise to further complications include Urticaria, Hypersensitivity reactions, Maculopapular rash, Eosinophilia, Drug fever, Phlebitis, Thrombophlebitis.The symptomatic adverse reactions produced by Cefamandole (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea.
Indications
Cefamandole (Na) is primarily indicated in conditions like Bone and joint infection, Cholecystitis, Peritonitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, Surgical prophylaxis, Urinary tract infection.
Interactions
Cefamandole (Na) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholProbenecidWarfarin (Na)Cefamandole may enhance the anticoagulant effect of Warfarin. ModerateMonitor for increased evidence of bleeding if Cefamandole is used concomitant with Warfarin.Cephalosporins that have an NMTT side chain in their chemical structure may pose the greater risk of interaction. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve reaction for glucose in urine with Benedicts or Fehlings or Clinitest Tabs. False +ve results for proteinuria using acid and denaturization precipation test.
Risks
Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Protect from Sunlight.
Warnings
Cefamandol should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).
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