Cefaclor (Monohydrate)

Cefaclor (Monohydrate) is a second generation cephalosporin antibiotic. Cefaclor (Monohydrate) is less effective against gram positive bacteria than first generation drugs. Cefaclor (Monohydrate) is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin and urinary tract infections. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in both structure and mode of action. Cephalosporin derived from fungus Cephalosporium. Cephalosporins have a six membered sulfur containing ring adjoining a β lactam ring. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed .Cefaclor (Monohydrate) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.


Brands
ALCEF ALCEF ALCEF ALCEF PROCLOR PROCLOR PROCLOR PROCLOR CECLOR MR CECLOR CECLOR CECLOR CECLOR CECLOR CECLOR CEFALOR CEFALOR CEFALOR CEFALOR CEFALOR CAVALOR CAVALOR CAVALOR CAVALOR CAVALOR ELICLOR ELICLOR ELICLOR ELICLOR NETTLE NETTLE NETTLE NETTLE REDYCLOR REDYCLOR REDYCLOR REDYCLOR REDYCLOR EPOCLOR EPOCLOR EPOCLOR EPOCLOR FEDCLOR FEDCLOR FEDCLOR FEDCLOR GEFLOR GEFLOR CETACLOR CETACLOR CETACLOR CETACLOR HICLOR HICLOR HICLOR HICLOR HICLOR EXLOR EXLOR EXLOR DUGEN DUGEN DUGEN DUGEN DUGEN MECLOR MECLOR MECLOR MECLOR RIDBAC RIDBAC RIDBAC RIDBAC RIDBAC VCLOR VCLOR VCLOR VCLOR NEUTROCLOR CLOROTIR CLOROTIR CLOROTIR CLOROTIR VYTRAM VYTRAM VYTRAM VYTRAM RICLOR RICLOR RICLOR RICLOR IDECEF IDECEF IDECEF IDECEF PEFACLOR PEFACLOR PEFACLOR PEFACLOR PHARCLORE PHARCLORE PHARCLORE PHARCLORE AMBICLOR AMBICLOR RECLOR RECLOR RECLOR RECLOR RECLOR KILBAC KILBAC KILBAC CLARACEF CLARACEF NIFLOR NIFLOR PLORSAF PLORSAF PLORSAF PLORSAF AG-CLOR AG-CLOR AG-CLOR AG-CLOR AG-CLOR DEUCEF DEUCEF SUPREN SUPREN DANVAR DANVAR DANVAR DANVAR CEFGARD FORTE CEFGARD CEFGARD CEFGARD CEFGARD TRINKLE TRINKLE TRINKLE TRINKLE TRINKLE TINKLE TINKLE TINKLE TINKLE ZANCLOR ZANCLOR ZANCLOR CORVIN CORVIN CORVIN CORVIN ORACLOR ORACLOR ORACLOR ORACLOR KANACLOR KANACLOR CYNIC CYNIC ACEF ACEF ACEF ACEF ACEF SLATE SLATE SLATE SLATE CEFAC CEFAC CEFAC CEFAC CEFA-Z CEFA-Z CEFA-Z CEFA-Z VALFACLOR VALFACLOR EROCLOR EROCLOR EROCLOR EROCLOR EROCLOR CLORCHAM CAMYON CAMYON CAMYON CAMYON DISTACLOR DISTACLOR DISTACLOR CEFAWAN CEFAWAN CEFAWAN CEFAWAN CEFCLOR CEFCLOR CEFCLOR CEFCLOR MEFACLOR MEFACLOR AMBIT AMBIT AMBIT AMBIT ALFALOR CAP ALFALOR CAP AFALOR AFALOR AFALOR AFALOR FACECLOR FACECLOR IPRA-CLOR IPRA-CLOR ZUPER ZUPER CEFOLUK CEFOLUK CEFOLUK CEFOLUK DINFRADIN DINFRADIN FYCLOR FYCLOR ROLEN ROLEN ROLEN ROLEN TOPCLOR TOPCLOR TOPCLOR TOPCLOR CEFLOCLOR CEFLOCLOR CEFANOL CEFANOL CEFANOL CEFANOL CEFANOL CAVEAT CAVEAT ZCLOR ZCLOR XECLOR LOWCLAR LOWCLAR LOWCLAR LOWCLAR KEFOLOR KEFOLOR KEFOLOR KEFOLOR CELOCEF CELOCEF CELOCEF CELOCEF N-CLOR N-CLOR N-CLOR N-CLOR CLORIZAT CLORIZAT CLORIZAT CLORIZAT CEDRATE CEDRATE CEDRATE CEDRATE MATRIX ENSPOR ENSPOR ENSPOR ENSPOR SHAFIX SHAFIX SHAFIX SHAFIX LEXICLOR LEXICLOR LEXICLOR LEXICLOR ABCLOR ABCLOR ABCLOR ABCLOR CEFACHLORMED CEFACHLORMED CEFACHLORMED CEFACHLORMED WNSALCLOR WNSALCLOR WNSALCLOR WNSALCLOR CECLOZONE CECLOZONE CECLOZONE CECLOZONE CARACLOR CARACLOR CARACLOR CARACLOR CARACLOR WISLOR WISLOR WISLOR WISLOR W CLOR W CLOR EPHACLOR EPHACLOR EPHACLOR EPHACLOR GCEF GCEF GCEF CROCEF CROCEF CROCEF CECLOADVAN CECLOADVAN CECLOADVAN ACLOR ACLOR ACLOR ACLOR SAMOCLOR SAMOCLOR SAMOCLOR FASICLOR FASICLOR ASTACLOR ASTACLOR ASTACLOR ASTACLOR AVECLOR AVECLOR AVECLOR AVECLOR SASCLOR SASCLOR WEFLOR WEFLOR WACLOR WACLOR WACLOR
Adult Dose
Dose: 250 to 750 mg
Single Dose: 500 (500)
Frequency: 8 hourly
Route: PO
Instructions:
Neonatal
Dose: 7 mg/kg
Single Dose: 7 (7)
Frequency: 8 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 7 mg/kg
Single Dose: 7 (7)
Frequency: 8 hourly
Route: Oral
Instructions: -
Characteristics
Cefaclor is the derivative of Cefaclor (Monohydrate). It is of Semi Synthetic origin and belongs to Cephalosporin. It belongs to Peptidoglycan synthesis inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotic, Cephalosporin-2nd Gen pharmacological group.The Molecular Weight of Cefaclor (Monohydrate) is 385.50. Its pKa is 8.03.
Contraindications
Cefaclor (Monohydrate) is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Cefaclor (Monohydrate), which give rise to further complications include Pseudomembranous colitis, Urticaria, Morbilliform eruptions.Cefaclor (Monohydrate) produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Cefaclor (Monohydrate) therapy.The signs and symptoms that are produced after the acute overdosage of Cefaclor (Monohydrate) include Nausea, Vomiting, Diarrhea.The symptomatic adverse reactions produced by Cefaclor (Monohydrate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Skin rashes, GI reactions, Genital candidiasis.
Indications
Cefaclor (Monohydrate) is primarily indicated in conditions like Arrhythmias after myocardial infarction, Bronchitis, Genitourinary tract infections, Otitis media, Pharyngitis, Pneumonia, Respiratory tract infections, Skin infections, Soft tissue infections, Tonsillitis.
Interactions
Cefaclor (Monohydrate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementEthacrynic AcidFrusemide or FurosemideGentamicincoadministration of gentamicin and cephalosporin (e.g cefaclor, cephaloridine) increase nephrotoxicity.ProbenecidTobramycincoadministration increase nephrotoxicity These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Abnormalities of AST(SGOT) and ALT(SGPT) values
Risks
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Oral Susp (reconstituted) Store in refrigerator. Do not Freeze. Use within 2 weeks if kept at room temperature. Tab, Caps, Dry Powder for Susp Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Cefaclor should be used with caution in patients with impaired liver or kidney function. Appropriate measure should be taken if secondary infection occurs.
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