THYRAZOL CARBIZOLE MERCAZOLE NEO-MERCAZOLE

Dose: 5 to 15 mg
Single Dose: 10 (10)
Frequency: 8 hourly
Route: PO
Instructions: Maintenance, for 6-18 Months

Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 8 hourly
Route: oral
Instructions:

Dose: 0.25 mg/kg
Single Dose: 0.25 (0.25)
Frequency: 8 hourly
Route: Oral
Instructions: -

. It is of Synthetic origin and belongs to Imidazoline. It belongs to Thyroid peroxidease inhibitor pharmacological group on the basis of mechanism of action and also classified in Antithyroid pharmacological group.The Molecular Weight of Carbimazole is 186.20.

Carbimazole is contraindicated in conditions like Nodular goitre,Sub-acute thyroiditis,Post-partum painless thyroiditis.

The severe or irreversible adverse effects of Carbimazole, which give rise to further complications include Cholestatic jaundice, Hepatic necrosis, Lupus like syndrome, Nephrotic syndrome, Insulin autoimmune syndrome.Carbimazole produces potentially life-threatening effects which include Agranulocytosis, Oropharyngeal bacterial infection. which are responsible for the discontinuation of Carbimazole therapy.The symptomatic adverse reactions produced by Carbimazole are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Fever, Loss of hair, Arthralgia, Urticarial skin rash, Vasculitis.

Carbimazole is primarily indicated in conditions like Blocking-replacement, Graves disease, Hyperthyroidism.

Carbimazole is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDigoxinPrednisolone and PrednisoneWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Tab Store Below 25°C.

Excessive dose of carbimazole (antithyroid) should not be used, because it may cause hypothyroidism or goiter Treatment should be discontinued immediately if there is any clinical or laboratory evidence of neutropenia. It is not recommended to use high dose during pregnancy or lactation.