L-Carnitine

L-Carnitine is amino acid derivative. It occurs naturally as an essential co-factor of fatty acid metabolism, which is synthesized endogenously or obtained from dietary source. Chemically L-Carnitine is identified as 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydoxide. L-Carnitine is involved in energy metabolism. L-Carnitine is used to treat carnitine deficiency. L-Carnitine is also used in persons with abnormal plasma lipoprotein patterns. L-Carnitine is administered orally and intravenously.

Brands
Adult Dose
Dose: 1 g
Single Dose: 1 (1)
Frequency: 8 hourly
Route: PO/IV
Instructions: not to exceed 3 g/d
Neonatal
Paedriatic
Characteristics
L-Carnitine also known as Levo-carnitine. . It is of Synthetic origin and belongs to Amino Acid. . The Molecular Weight of L-Carnitine is 161.20. It is weakly acidic drug and Its pKa is 3.8.
Contraindications
L-Carnitine is contraindicated in conditions like Hypersensitivity.
Effects
The symptomatic adverse reactions produced by L-Carnitine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Abdominal cramps, Drug-related body odor.
Indications
L-Carnitine is primarily indicated in conditions like Myopathic carnitine deficiency, Primary carnitine deficiency, Secondary carnitine deficiency, Systemic carnitine deficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Myocardial ischaemia, Skeletal muscle ischemia, Valproate-induced hepatotoxicity.
Interactions
No data regarding the interactions of L-Carnitine was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Tab, Liq, Caps Store Below 40°C. Protect from Sunlight and Heat.
Warnings
L-carnitine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any pre-existing illness or allergy. Pateints with severe renal impairment should not be given high oral doses of levo carnitine.
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