CALCIUM FOLINATE LEUCOFOLATE LEUCOCIN LEUCOCIN LEUCOCIN LEUCOCIN CALCIUM FOLINATE

Dose: 75 mg
Single Dose: 75 (75)
Frequency: 12 hourly
Route: IV
Instructions: Treatment of overdaosage of folic acid antagonists: This dose is followed by 12 mg IM every 6 hours for 4 doses.

Calcium Folinate also known as Calcium Leucovorin. . It is of Synthetic origin. . The Molecular Weight of Calcium Folinate is 511.50. It is weakly acidic drug.

Calcium Folinate

The severe or irreversible adverse effects of Calcium Folinate, which give rise to further complications include Urticaria, Anaphylactoid reactions.The symptomatic adverse reactions produced by Calcium Folinate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Hypersensitivity reactions.

Calcium Folinate is primarily indicated in conditions like As an antidote to methotrexate, Folate deficiency anaemia, Megaloblastic anaemia, Nausea and vomiting, Suspected methotrexate overdosage, To counteract the folate-antagonist action of methotrexate, and can also be given in adjunctive therapy as an alternative drug of choice in HIV infection.

No data regarding the interactions of Calcium Folinate was found.

If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Injection Protect from Sunlight. Tab Store in a well closed container. Protect from Sunlight.

alcium Folinate should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents. In the treatment of inadvertent overdosage of a folic acid antagonist, folinate should be administered as soon as possible; if a period exceeding 4 hours intervenes, the treatment may not be effective.Plasma methotrexate concentration, BUN and creatinine should be measured on days 2, 3 and 4.Parenteral administration of folinate is preferable to oral dosing following chemotherapy with folic acid antagonists if there is a possibility that the patient may vomit and not absorb the folinate.