Phenazone

Phenazone is antipyretic, analgesic, reduces fever and relieves pain. Phenazone is used topically as a local anesthetic. Phenazone is rarely used, often found in analgesic mixtures and in otic (ear) preparations.


Brands
Adult Dose
Dose: 2 to 4 drops
Single Dose: 3 (3)
Frequency: 6 hourly
Route: Otic
Instructions:
Neonatal
Paedriatic
Characteristics
Phenazone also known as Antipyrine. . It is of Synthetic origin and belongs to Pyrazolin. . The Molecular Weight of Phenazone is 188.20. Its pKa is 1.4.
Contraindications
Phenazone is contraindicated in conditions like Hypersensitivity to the drug.
Effects
The severe or irreversible adverse effects of Phenazone, which give rise to further complications include Hemolytic anemia, Hemolytic anemia, Hypersensitivity reactions, Porphyria.Phenazone produces potentially life-threatening effects which include Coma, Convulsions. which are responsible for the discontinuation of Phenazone therapy.The symptomatic adverse reactions produced by Phenazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Nausea, Skin eruptions.
Indications
Phenazone is primarily indicated in conditions like Inflammation, Otitis media, Pain.
Interactions
Phenazone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDisulfiram These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Ear Drops, Solutions Store in a well closed container. Protect from Sunlight and Moisture.
Warnings
It should not be used in patients having family history of perforated lymphatic membrane.
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