Magnesium Sulphate

Magnesium Sulphate is a saline laxative. Magnesium Sulphate is used in constipation. It increases the bulk of intestinal contents and cause defecation. Magnesium Sulphate is also used to control seizures in pregnancy, to treat low magnesium levels, problems related to kidney conditions (nephritis) in children, to prevent premature contractions in pregnancy, to treat heart attack and asthma patients.

Brands
MAG-S LACTOCAL SANTEVINI PLUS VITALET-M VITALET-H MAGNESIUM SULPHATE MAGNESIUM SULPHATE
Adult Dose
Dose: 1 to 2 g
Single Dose: 1.5 (1.5)
Frequency: 6 hourly
Route: IV,IM
Instructions: As required.
Neonatal
Paedriatic
Characteristics
. It is of Synthetic origin. . The Molecular Weight of Magnesium Sulphate is 246.50. It is weakly acidic drug.
Contraindications
Magnesium Sulphate is contraindicated in conditions like Myocardial infarction,Heart block,Toxaemia of pregnancy,Renal impairment.
Effects
The severe or irreversible adverse effects of Magnesium Sulphate, which give rise to further complications include Diarrhoea, Bradycardia, CNS depression, Hypocalcemia, Hypermanganesemia.Magnesium Sulphate produces potentially life-threatening effects which include Coma, Cardiac Arrest, Cardiac arrest, Respiratory paralysis. which are responsible for the discontinuation of Magnesium Sulphate therapy.The symptomatic adverse reactions produced by Magnesium Sulphate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Drowsiness, Confusion, Hypotension, Flushing, Muscle weakness, Nausea and vomiting, Slurred speech, Respiratory depression, Confusion.
Indications
Magnesium Sulphate is primarily indicated in conditions like Constipation, Convulsions, Eclampsia, Emergency treatment of serious arrhythmias, Hyperacidity, Hypomagnesaemia, Nephritis, Prevention of seizure recurrence in pre-eclampsia, Seizures, Suspected myocardial infarction, Symptomatic hypomagnesaemia, To prevent recurrence of defecits, and can also be given in adjunctive therapy as an alternative drug of choice in Premature labour.
Interactions
Magnesium Sulphate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementMonobasic sodium phosphateNifedipineRitodrine (HCl)Magnesium Sulphate may potentiate cardiovascular effects of intravenous ritodrine, especially cardiac arrhythmias or hypotension.Suxamethonium (Cl)Tetracycline (HCl)Tubocurarine (Cl) Vecuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store Below 40°C. Protect from Sunlight and Moisture.
Warnings
Do not exceed prescribed dose because it will cause diarrhea.Maintain urine output at level of 100ml every 4hrs.
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