ACTHAR GEL

Dose: 80 to 120 units/day
Single Dose: 100 (100)
Frequency: As recommended.
Route: IM
Instructions: Acute Exacerbations of Multiple Sclerosis: should be injected for 2 to 3 weeks.

Dose: 75 unit/m2
Single Dose: 75 (75)
Frequency: As recommended.
Route: I/M
Instructions: under 2 year of age. Twice daily over a 2 weeks period, then gradually taperod over adrenal insuffication.

Dose: 40 to 80
Single Dose: 60 (60)
Frequency: As recommended.
Route: I/M or S.C
Instructions: Over 2 years of age. every 24 to 72 hours.

Corticotropin also known as Corticotrophin. . It is of Natural origin. . The Molecular Weight of Corticotropin is 4567.60. It is strongly acidic drug.

Corticotropin is contraindicated in conditions like Hypertension,Peptic ulcer,Osteoporosis,Congestive heart failure,Surgery.

The severe or irreversible adverse effects of Corticotropin, which give rise to further complications include Convulsions, Hypertension, Diabetes, Anaphylaxis, Pneumonia, Necrotizing angiitis, reaction, hypertrophy.Corticotropin produces potentially life-threatening effects which include Cerebral hemorrhage, Cerebral hemorrhage. which are responsible for the discontinuation of Corticotropin therapy.The symptomatic adverse reactions produced by Corticotropin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Nausea, Vomiting, Muscle weakness, dizziness, sodium and water, potassium loss, retention.

Corticotropin is primarily indicated in conditions like All forms of epilepsy, Diagnostic (adrenal cortex), Hypercalcaemia, Neurological disorders, Tuberculosis.

Corticotropin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAspirinKetoconazolePhenobarbitonePhenytoin (Na)RifampicinRitodrine (HCl)Corticosteroids are often used concurrently to enhance fetal lung maturity. Intravenous ritodrine and, to a lesser extent, corticosteroids each expand plasma volume by causing sodium retention. Rotavirus vaccineThe administration of live, attenuated virus or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received Corticotropin.ModerateIn general, live virus or bacterial vaccines should not be used in patients receiving Corticotropin.Sodium ChlorideCaution must be exercised in the administration of Sodium Chloride Injection corticotropin.SomatropinSomatropin administration may alter the clearance of Corticotropin.Tiaprofenic AcidCorticotropin may increase the risk of GI ulceration.Avoid concurrent use. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Suppression of skin test reaction

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Inj (reconstituted soln) Store at room temperature or refrigerator. Use within 24 hrs if kept at room temperature. Susp Store in a well closed container, Below 25°C. Protect from Sunlight.

Corticotropin should be used with caution in patients with active tuberculosis infection of respiratory tract or in untreated fungal, bacterial or systemic viral infections. Corticosteroids should only be used systemically with great caution in the presence of congestive heart failure (CHF), recent myocardial infraction (MI), hypertension, diabetes mellitus, epilepsy, glaucoma, hypothyroidism, liver failure, osteoporosis, peptic ulceration or renal impairment. Children may be at increase risk of some adverse effects, corticosteroid causes growth retardation and prolonged use is rarely justified. Passive immunization is recommended to non-immune patients who do come in contact with chickenpox or measles. Live vaccine should not be given to patients receiving high dose systemic corticosteroid therapy nor for atleast 3months afterwards, killed vaccine or toxoids may be given, although the response may be attenuated. During prolong treatment with corticosteroids, patients should be examined regularly, sodium intake may need to be reduced and calcium and potassium supplement may be necessary. Patient should carry cards given full details of their corticosteroid therapy. Avoid use during pregnancy. Use nasal steroids with caution until healing has occurred.