Calcitriol

'Calcitriol is a 1, 25-dihydroxycholecalciferol (vitamin D), a fat soluble sterol, sometimes considered to be hormone or hormone precursor. Vitamin D is involved in promoting normal bone development in body by regulating calcium, phosphorus and minerals. Vitamin D is a secosteroid and sometimes popularly known as the ''sunshine vitamin'' because formed in the skin from 7-dehydrocholesterol under the influence of ultraviolet irradiation. Calcitriol is also found in certain food. Fish liver oils, especially code liver oil are good sources of vitamin D. Calcitriol has been used in the management of psoriasis.'


Adult Dose
Dose: 0.25 to 1 mcg
Single Dose: 0.62 (0.625)
Frequency: 24 hourly
Route: PO
Instructions:
Neonatal
Dose: 0.01 to 0.05 ug/kg
Single Dose: 0.03 (0.03)
Frequency: 24 hourly
Route: Oral
Instructions: -
Paedriatic
Dose: 0.01 to 0.05 ug/kg
Single Dose: 0.03 (0.03)
Frequency: 24 hourly
Route: Oral
Instructions: -
Characteristics
Calcitriol also known as 1, 25 Dihydroxy Vitamin D3. Vitamin D is the derivative of Calcitriol. It is of Synthetic origin and belongs to Vitamin D. It belongs to Vitamin D agonist pharmacological group on the basis of mechanism of action and also classified in Vitamin D Analogue pharmacological group.The Molecular Weight of Calcitriol is 416.00.
Contraindications
Calcitriol is contraindicated in conditions like Hypercalcaemia.
Effects
The severe or irreversible adverse effects of Calcitriol, which give rise to further complications include Urinary calcium stone formation, Urinary calcium stone formation.Calcitriol produces potentially life-threatening effects which include Depression of CNS, Coma, Ectopic mineralization. which are responsible for the discontinuation of Calcitriol therapy.
Indications
Calcitriol is primarily indicated in conditions like Hypocalcaemia, Hypophosphataemia, Oncogenic hypophosphatemic osteomalacia, Renal tubular osteomalacia, Sporadic hypophosphatemic osteomalacia, Uraemic osteodystrophy, Uremic osteodystrophy, Vitamin D-dependent rickets, and can also be given in adjunctive therapy as an alternative drug of choice in Neonatal hypocalcemia, Osteomalacia, Osteomalacia in malabsorption syndrome, Osteoporosis, Psoriasis, Rickets in premature infants, X-linked hypophosphataemic osteomalacia.
Interactions
Calcitriol is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAluminium Hydroxide and OxideCholestyramineColestipol (HCl)DigoxinVORICONAZOLEVoriconazole may increase the serum concentration of calcitriol by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of calcitriol if voriconazole is initiated, discontinued or dose changed. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Assay for plasma Vit. D metabolites (at high doses)
Risks
Drug should not be given to Paediatrics, patients suffering from Kidney dysfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Caps Store in a well closed container, Below 40°C. Protect from Heat.
Warnings
Evaluate Vit.D administration in fortified food, diet and drugs. It may be necessary to limit dietary Vit.D during treatment. If products of Vit.D contain tartrazine may cause allergic reaction (Including bronchial asthma) in susceptible individuals, Specially patients with aspirin hypersensitivity.
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