Calcitonin

Calcitonin is a single chain peptide hormone with 32 amino acids, secreted by the thyroid gland. A disulfide bond between positions 1 and 7 is essential for its biologic activity. It plays an important role in calcium and bone metabolism, inhibits bone resorption and acts as an antagonist to parathyroid hormone.

Brands
Adult Dose
Dose: 7.14 ug/kg
Single Dose: 7.1 (7.14)
Frequency: 24 hourly
Route: SC
Instructions: -
Neonatal
Dose: 4 to 8 IU/kg
Single Dose: 6 (6)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: As Required
Paedriatic
Dose: 4 to 8 IU/kg
Single Dose: 6 (6)
Frequency: 24 hourly
Route: Intra Muscular
Instructions: As Required
Characteristics
. It is of Synthetic origin and belongs to Polypeptide. It belongs to Calcitonin agonist pharmacological group on the basis of mechanism of action and also classified in Antidotes pharmacological group.The Molecular Weight of Calcitonin is 3418.00. Its pKa is -.
Contraindications
Calcitonin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Calcitonin, which give rise to further complications include Vomiting, Rhinitis, Rhinitis, Abdominal pain, Hypersensitivity reactions, Oedema, Cough, Anaphylactic reactions, Diuresis, Throat Irritation, Musculoskeletal pain, Taste disturbance.The signs and symptoms that are produced after the acute overdosage of Calcitonin include Transient vomiting.The symptomatic adverse reactions produced by Calcitonin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Diarrhea, Fever, Rashes, Itching, Flushing, Loss of appetite, dizziness, rashes.
Indications
'Calcitonin is primarily indicated in conditions like Bone (pagets) disease, Bone pain in neoplastic disease, Hypercalcaemia, Metastatic bone pain, Osteoporosis, Paget''s disease of bone, Sudeck''s atrophy, Treatment of osteoporosis in post menopausal women.'
Interactions
Calcitonin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAmlodipine (Besylate)Pamidronate (Disodium Pentahydrate) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Aerosol Store in a well closed container. Protect from Sunlight and Heat. Inj Store in a well closed container. Do not Freeze. Protect from Sunlight and Heat.
Warnings
Skin testing should be considered before treating with calcitonin, especially for patients with susceptible sensitivity. Because calcitonin is a protein so there is a possibility of systemic allergic reactions, if there is, then stop therapy and manage the conditions accordingly.Ihibit lactation in animals.Use with caution in Renal Impairement patients,avoid unless potential benefits outweight risk.
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