Influenza Vaccine

Influenza Vaccine is a sterile aqueous suspension of suitable strain or strains of influenza virus types A and B, either individually or mixed, grown individually in embryonated hen eggs and inactivated so that they retain their antigenic properties. The composition of vaccine is changed every year in respose to antigenic shifts and changes in prevalence of influenza virus strain. The vaccine is usually bivalent or trivalent, containing one or two influenza virus A strains and one influenza virus B strain. Annual immunization before November is recommended for high risk individuals (persons over 65 years of age and persons with chronic disease). Influenza Vaccine is used for active immunization against influenza, Influenza Vaccine is indicated only for immunization against those strains of viruses from which the vaccine is prepared or against closely related strains.

Brands
FLUARIX ACT-HIB VAXIGRIP AGRIPPAL-S1 INFLUENZA MIXTURE TETRACT-HIB PENTACT-HIB QUIMI-HIB
Adult Dose
Dose: 0.5 ml
Single Dose: 0.5 (0.5)
Frequency: As recommended.
Route: IM
Instructions: Once,Same for different age group
Neonatal
Paedriatic
Dose: 0.25 to 0 ml
Single Dose: 0.12 (0.125)
Frequency: As recommended.
Route: 6 months - 3 years the 2nd dose should be given 4 weeks after the first dose.
Instructions:
Characteristics
. It is of Semi Synthetic origin. It belongs to Vaccines pharmacological group.
Contraindications
Influenza Vaccine is contraindicated in conditions like Thrombocytopenia,Hypersensitivity,Febrile illness.
Effects
The severe or irreversible adverse effects of Influenza Vaccine, which give rise to further complications include Convulsions, Thrombocytopenia, Angioedema, Angioedema, Neuralgia, Neuritis, Encephalomyelitis, Guillian-Barre syndrome.The symptomatic adverse reactions produced by Influenza Vaccine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Urticaria, Pain, Allergic reactions, Redness, Malaise, Swelling, Anaphylactic shock, Paresthesias, Tenderness, Flue like syndrome.
Indications
Influenza Vaccine is primarily indicated in conditions like Influenza prophylaxis.
Interactions
Influenza Vaccine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCarbamazepineOseltamivirAntiviral agents that are active against influenza A and/or B viruses may conceivably interfere with the immunogenicity of live influenza virus vaccine by inhibiting the replication of vaccine virus. However, the potential for interaction has not been evaluated.MajorLive influenza virus vaccine should not be administered until at least 48 hours after the cessation of antiviral therapy. Antiviral agents should not be administered until two weeks after immunization with live influenza virus vaccine unless medically indicated. If antiviral agents and live influenza virus vaccine are administered concomitantly, revaccination should be considered when appropriate.PhenobarbitonePhenytoin (Na)Rho (D) Immune Globulin Antibodies found in immune globulins may interfere with the immune response to live vaccines.ModerateVaricella vaccine should not be given for at least 5 months after, and other live vaccines should not be given for at least 3 months after administration of immune globulin.TheophyllineWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
False +ve result in serology tests using ELISA method to detect antibodies against HIV, hepatitis C.
Risks
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj Store in refrigerator. Do not Freeze. Protect from Sunlight.
Warnings
Influenza vaccine should be used only if clearly needed during pregnancy or lactation. It should be used with caution in patients with any illness, infection or if have any allergy especially to eggs or egg products. The administration of the vaccine should be postponded in subjects suffering from acute febrile illness. The Vaccine only prevent the disease caused by influenza virus, infection with other agents causing flu-like symptoms are not prevented by influenza vaccine. Appropriate medical treatment and supervision should always be readily available in case of a rare anaphylactic reactions following the administration of the vaccine.
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