Levosulpiride

Levosulpiride is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors. Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses such as schizophrenia, anxiety disorders, vertigo and also in peptic ulceration.


Adult Dose
Dose: 200 to 800 mg
Single Dose: 500 (500)
Frequency: 24 hourly
Route: IM
Instructions:
Neonatal
Dose:
Single Dose:
Frequency:
Route:
Instructions: Not recommended in this age group
Paedriatic
Dose: 3 to 5 mg/kg
Single Dose: 4 (4)
Frequency: As recommended.
Route: PO
Instructions: This is the dose for children above 14 years of age. (i.e. 3-5mg/Kg daily)
Characteristics
belongs to Sulphamoylbenzamide. It belongs to D2 antagonist pharmacological group on the basis of mechanism of action and also classified in Psychotherapeutic Drugs and Antidepressant pharmacological group.The Molecular Weight of Levosulpiride is 341.40. It is weakly alkaline drug.
Contraindications
Levosulpiride is contraindicated in conditions like Epilepsy,Hyperprolactinaemia,Mania,Gastrointestinal hemorrhage,pheochromocytoma,Breast feeding,Hypersensitivity to any component of product.
Effects
The severe or irreversible adverse effects of Levosulpiride, which give rise to further complications include Amenorrhea, Gynacomastia, Galactorrhea, Changes in libido.Levosulpiride produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Levosulpiride therapy.The symptomatic adverse reactions produced by Levosulpiride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sedation, Sleep disturbance, Hypotension, Gynecomastia, Galactorrhea, Agitation, Dyskinesia, Overstimulation, Hyperprolactinemia, Tardive dyskinesia.
Indications
'Levosulpiride is primarily indicated in conditions like Anxiety, Depression, Gastro-esophageal reflux disease, Irritable bowel syndrome, Schizophrenia, Tourette''s syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Peptic ulcer, Vertigo.'
Interactions
No data regarding the interactions of Levosulpiride was found.
Interfrence
Risks
Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Warnings
Should be use with caution in porphyria,renal impairment and mania and in patients receiving antihypertensive, hypnotic and analgesic drugs, because concurrent use may increase the effects of these drugs.should be given with care to hypomanic pateints.
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