Levofloxacin

Levofloxacin is a fluoroquinolone antibiotic available for oral or intravenous administration. Levofloxacin is the optically active L-isomer of ofloxacin. It has a slightly longer half-life than ofloxacin and can be administered once-daily. Levofloxacin is more active than ofloxacin against staphylococci and streptococci. Levofloxacin is FDA approved for the treatment of sinusitis, chronic bronchitis, community-acquired pneumonia, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. It tablets and injection were FDA approved for the treatment these infections on 12/20/96. It inhibits bacterial DNA gyrase, a type II topoisomerase. Topoisomerases alter DNA by introducing superhelical twists into double-stranded DNA and by facilitating unwinding of DNA strands


Brands
ATCOFLOX ATCOFLOX TAVANIC TAVANIC TAVANIC ALIXIN ALIXIN FEELIX FEELIX BENALOX BENALOX LEGREAT LEGREAT DELVOCIN DELVOCIN GEN-LEVO GEN-LEVO GEN-LEVO LEOFLOX LEOFLOX QUMIC QUMIC QUMIC QUMIC QLENA QLENA ELOCIN AEROBAY AEROBAY DYNAQUIN DYNAQUIN DYNAQUIN LEVAQUIN LEVAQUIN LEVOCIL LEVOCIL LEVOCIL LEVOCIL FLOXER FLOXER LINATIC LINATIC LOVENOX LOVENOX TOPOCID TOPOCID TOPOCID QFIN QFIN ZEEVOFLOXACIN ZEEVOFLOXACIN PULVILOX PULVILOX LEVO LEVO LEETAB LEETAB EPOVEL EPOVEL EPOVEL LEEFED OPTICIN EPLALEV EPLALEV LEVERNI LEVERNI MORAX LEVOVIS LEVOVIS LEVOMAY LEVOMAY LEVANIC LEVANIC LEVANIC LEVANIC LEVANIC LEVANIC FLOXIMED FLOXIMED KINGFLOXIN LEFLOX LEFLOX LEFLOX LEFLOX LEFLOX VOLFLOXACIN VOLFLOXACIN VOXIQUIN INFUSION CRAVIT CRAVIT CRAVIT LCYN LCYN TURBONIC TURBONIC TUBONIC TUBONIC XEFLOX XEFLOX XEFLOX XEFLOX XEFLOX S-FLOX S-FLOX LOGIFLOX STARLEV STARLEV STARLEV LEVOTEL LEVEE LEVEE MCLEVO MCLEVO MCLEVO LEVOZOR LEVOZOR LEVOXOR KOBEXIN KOBEXIN TYCHO TYCHO LEVOXACIN LEVOXACIN TEFNEL TEFNEL LEVOMED LEVOMED LEVOMED LEOVIN LEOVIN LEOVIN LEOVIN QUVOXIN QUVOXIN EVAXOSURE EVAXOSURE LEON LEON LEVITE LEVITE LEVITE WARIOR WARIOR WARIOR WARIOR LEFOXIN LEFOXIN LEFOXIN LEVOFIN LEVOFIN LEVOFIN LEVORT LEVORT LEVO F LEVO F EVERBACT OB-FLOX LEVONEN LEVONEN NEOQULON NEOQULON IOVANIC IOVANIC IOVANIC LEVOMERC LEVOMERC QUEST QUEST QUEST SPECTRIX SPECTRIX TEVOFLOX TEVOFLOX TEVOFLOX LEFLOTEC LEFLOTEC PFIZIFLOX PFIZIFLOX EXMIC EXMIC LEVONIC LEVONIC FOVEL FOVEL CINQUIN CINQUIN INFLOX INFLOX LEXOF LEXOF LEXOF LEXOF REVOCIN REVOCIN KAVOFLOX KAVOFLOX FLOXOLEV FLOXOLEV LEVORX LEVORX LEVORX SAVELOX SAVELOX PLIFLOX PLIFLOX LEVOPAL LEVOPAL EFFIFLOX EFFIFLOX EFFIFLOX QINDON QINDON LEVOXIN LEVOXIN GLIT GLIT VOTEC LAVILOX LAVILOX LEFEXY LEFEXY LEFEXY MAXLEVO MAXLEVO BEXUS BEXUS BEXUS BEXUS BEXUS BEXUS BEXUS BEXUS BEXUS-500 MOSL VE MOSL VE PELIKAN PELIKAN GETQUIN VIZOR VIZOR PULMOFLOX PULMOFLOX PULMOFLOX STANFLOX STANFLOX STANFLOX NEUMO NEUMO NEUMO NEUMO VOFLOZA VOFLOZA EFFIQUIN EFFIQUIN PROTEKTIN PROTEKTIN LEVOBAY LEVOBAY BRODIN BRODIN LEVOCIN INFUSION AKSOLOX AKSOLOX AKSOLOX AKSOLOX KEVOX KEVOX HECTOR HECTOR FINLIVE FINLIVE LEVOPATH LEVOPATH LEVATAZET LEVATAZET LIVESTA LIVESTA LEVLONG LEVLONG E-LEV E-LEV BESTOLEV NABOQUINE TRICE TRICE TRICE TRICE TRICE REVONIL REVONIL LEFLOCIN LEFLOCIN LEVESTA LEVESTA LOCUS LOCUS LEQUIX OXA-Z OXA-Z OXA-Z XVEL LECIN LECIN LE-SIVE LE-SIVE OLIZA OLIZA OLIZA LEVARD LEVARD LEVOGLOBIN LEVOGLOBIN MEDILEVO MEDILEVO STANDLO STANDLO EIVOCIN EIVOCIN LOVAFAM LEVOFAM LEVLOX LEVOSAFE LEVODAY LEVODAY CROCUS CROCUS CELADOR CELADOR OLEVO OLEVO LEVOLEX TABLET LEVOLEX TABLET LEVOLEX TABLET LEVOGEN LEVOGEN LEVOGEN LEVOGEN CAYLEV CAYLEV FARLEO FARLEO QUINOCIL QUINOCIL LOXYCIN LOXYCIN LENON LENON MAFOX LEVOHEIM LEVOSCOT LEVOSCOT VOFLOX VOFLOX F OXACIN F OXACIN QUINOLEV QUINOLEV ASILIX ASILIX LEVOXSEL LEFNIL LEFNIL XALVIN XALVIN LEVOTRIM LEVOTRIM VOXIQUIN TABLET VOXIQUIN TABLET CYNOXIN CYNOXIN ZEVO ZEVO XALVO XALVO SAMLEVO SAMLEVO SANFLOX SANFLOX SANFLOX LEVONAG LEVONAG LEVOFIN SUSPENSION LEVOFIN SUSPENSION LEVOFIN SUSPENSION KAMFLOX XR EVERFLOX EVERFLOX EVERFLOX MEDLEVO MEDLEVO LEVOR LEVOR LEVOR LEVASIA LEVASIA LURK LURK NOAFLOX NOAFLOX LEOCIN LEOCIN LASIFLOX LASIFLOX AWARAX AWARAX LEVOCIN TABLET LEVOCIN TABLET LEVOFLOXA LEVOSYN LEVOSYN LOXIWELL LOXIWELL LEVOCURE LEVOCURE LEVOCURE LEVOCURE OVILOX OVILOX LEVYAN LEVYAN LEVOFAZ LEVOFAZ LEZOV LEZOV LEZOV LEZOV LEVOK LEVOK JEVELEXIN JEVELEXIN LEVOLEX SUSPENSION LEVOLEX SUSPENSION AXOLOX AXOLOX LEVODEN LEVODEN DAVANIC DAVANIC NIAQUIN NIAQUIN CUBAC CUBAC MACLIVE PENETREX PENETREX LEVOSOL I.V LEVOLIFE LEVOLIFE LEVOLIFE VELOXEN VELOXEN LEVOMAC AXOLEV AXOLEV WEBOQUIN WEBOQUIN WEBOQUIN LIJID LIJID LEVOFEND LEVOFEND LEVOTRIL LEVOTRIL GEPHOXIN GEPHOXIN LEVOCID LEVOCID LEVILOX LEVILOX STERILEVO BELEVO BELEVO ALIGANT ALIGANT VINZ VINZ ALOVIC ALOVIC LEEMAX LEEMAX LEVOFLOMED LEVOFLOMED LEVOFLOMED LEVOFLOMED LE-4 LE-4 FYLONE FYLONE ANTON ANTON LEVOBACT LEVOBACT LEVOX LEVOX INFECURE INFECURE INFECURE LAZER LAZER TRIG TRIG LEXOMED LEXOMED VAFLOX VAFLOX KIVCIN KIVCIN LEVOSON LEVOSON WOFF WOFF TRIWAY THELEVO THELEVO THELEVO SURMOUNT SURMOUNT SURMOUNT SURMOUNT HAMFLOX HAMFLOX QUEZAN QUEZAN LE-CAP LE-CAP LEVOGREEN LEVOGREEN LEVOPHARM LEVOPHARM OSELIV OSELIV LEVOGOOD LEVOGOOD LEVOGOOD LEVOGOOD LOTOFLOX LOTOFLOX HYGRADE HYGRADE HYGRADE KLUG KLUG CURATIF CURATIF LEVOQUIN LEVOQUIN LEVIN LEVOCAP LEVOCAP LEOX LEOX NANO-BID NANO-BID LEVROGEN LEVROGEN LEVENX LEVENX LE-ONE LE-ONE LE-ONE QUCIN QUCIN LEVOWAN LEVOWAN LEVOSHINE LEVOSHINE MARIFLOX MARIFLOX MEVOFLOX MEVOFLOX VERALOX VERALOX HEVOSYN HEVOSYN VOKSEC VOKSEC VOFLOX TABLET W-LEVO W-LEVO BACTHROW BACTHROW LEVOTAR SELFLOX SAFQUIN LIVLE LIVLE LEVOMINE LEVOGIL LEVOGIL LEVOMIN LEVOMIN ORALEVO ORALEVO LIVONIC TABLET LIVONIC TABLET IFLOSIN L-OXCIN L-OXCIN LIVONIC INFUSION RAYLOX RAYLOX RAYLOX SAYVOF KLUST KLUST KLUST VOXCEN VOXCEN MEQUIN MEQUIN NU-LEVO NU-LEVO NU-LEVO CRESLEVO CRESLEVO UNILEVO UNILEVO NULEVO NULEVO NULEVO MEDAC MEDAC BEST LEVO BEST LEVO BEST LEVO BRAVIT BRAVIT MYROLEVE LEVOSAT LEXA LEXA ADLEVO ADLEVO LEVIP LEVIP WEVOFLOXIN WEVOFLOXIN LEVOBACT INFUSSION LEEON LEEON SILOX SILOX LEVOTREAT OVELCIN MONTLEVO MONTLEVO MONTLEVO
Adult Dose
Dose: 500 mg
Single Dose: 500 (500)
Frequency: 12 hourly
Route: IV
Instructions:
Neonatal
Paedriatic
Dose: Not recommende for this age group
Single Dose:
Frequency:
Route:
Instructions:
Characteristics
. It is of Semi Synthetic origin and belongs to Piperazine. It belongs to DNA Gyrase inhibitor pharmacological group on the basis of mechanism of action and also classified in Antibiotics pharmacological group.The Molecular Weight of Levofloxacin is 361.40.
Contraindications
Levofloxacin is contraindicated in conditions like Hypersensitivity.
Effects
The severe or irreversible adverse effects of Levofloxacin, which give rise to further complications include Stevens johnson syndrome, Epidermal necrolysis, Stevens johnson syndrome, Epidermal necrolysis, Tendon rupture, QT prolongation.Levofloxacin produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Levofloxacin therapy.The signs and symptoms that are produced after the acute overdosage of Levofloxacin include QT prolongation.The symptomatic adverse reactions produced by Levofloxacin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Diarrhea, Anxiety, Restlessness, Constipation, Abdominal pain, Confusion, Pruritus, Vaginitis, Hallucination, Dyspepsia, Depression, Nightmares, Chest pain, Hypoglycemia, Confusion, dizziness, dyspepsia.
Indications
Levofloxacin is primarily indicated in conditions like Acute pyelonephritis/prostatitis, Bronchiolitis, Bronchitis, Complicated UTIS, Folliculitis, Nephrogenic and partial pituitary diabetes insipidus, Oedema, Otitis externa, Pneumonia, Pyelonephritis, Respiratory tract infections, Short-term treatment of severe congestive heart failure, Skin and soft tissue infections.
Interactions
Levofloxacin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAluminium Hydroxide and OxideAluminium and magnesium hydroxide containing antacids, and products containing calcium, ion and zinc salts reduce the absorption of levofloxacin.Cyclosporin AConcomitant use of levofloxacin and cyclosporin increases nephrotoxicity.FenbufenUse of fenbufen with quinolones may increase the incidence of quinolone CNS adverse effects.ProbenecidThe urinary excretion of levofloxacin is reduced by probenecid; plasma concentration are not necessarily increased.TheophyllineLevofloxacin decrease the clearance of theophylline and caffeine.VORICONAZOLEAdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongationWarfarin (Na)Levofloxacin enhances the effect of oral anticoaggulants. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Interfrence
Elevation in BUNFalse-positive urine screening resultsFalse-positive urine screening resultselevated creatinine
Risks
Drug should not be given to Paediatrics, Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Storage
Inj (Reconstituted soln) Store at room temperature or refrigerator. Do not Freeze. Protect from Sunlight and Heat. Use within 2 weeks if refrigerated and within 2 weeks if kept at room temperature. Tab Store Below 30°C. Protect from Sunlight and Moisture.
Warnings
Levofloxacin should be used with caution in patients with epilepsy, kidney disease, tendon problems, nervous system disorders, liver disease and of any allergy, including drug allergy. It should be used with caution while driving or performing tasks requiring alertness because it causes dizziness, lightheaded or drowsiness. Limit alcohol intake. Because this may cause sensitivity to the sun, so avoid prolonged sun exposure, wear protective clothing and use a sunscreen when outdoors. Caution is advised when this drug is used in children under 18 years of age. It should be used only when clearly needed during pregnancy. It is not recommended during lactation.
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